Focus on Infectious Disease
Recently, we've seen an explosion of new information about the basic biology of pathogens and how a host responds to infection. We're using this new information to develop new medicines and technologies that combat serious bacterial and viral infections, such as HCV.
In the department of microbial pathogenesis we're focused on understanding the molecular mechanisms of disease and developing of novel technologies to interrupt pathogenic events. We're also exploring new ways to deliver therapeutics to the site of infection, that are both more efficient at pathogen elimination and less toxic to the host.
Recent AccomplishmentsPublication: PLoS Pathog, May 2009
Atg5-independent sequestration of ubiquitinated mycobacteria
Here we show that cytosolic access results in a new and intricate host pathogen interaction: host macrophages ubiquitinate Mm, while Mm shed their ubiquitinated cell walls.