Andrew Chan

Senior Vice President, Immunology

POSTDOC MENTOR

"Innovation requires an open mind and continued challenging of current paradigms. Discovery requires action based on innovation."

• 12
  years at Genentech
• 10
  publications (2010-12)
• 8
  awards & honors

I joined Genentech in 2001 as senior director of immunology and antibody engineering, was named vice president and senior vice president of Research- Immunology in 2003 and 2007, respectively. In 2010, I was appointed senior vice president- Research Biology and oversee our major focus areas of oncology, immunology, neuroscience, and infectious disease, as well as investigation into new scientific opportunities.

I decided to join Genentech because it permitted me to combine my interests in basic discovery research with my translational interests in understanding the underlying pathogenesis of human autoimmune and inflammatory disorders. I was drawn to Genentech because of its grassroots scientist-driven environment where scientific rigor, innovation and collaboration intertwine basic research and translational medicine and challenge the intellect to discover impactful innovative therapies for significant medical problems.

Technological advances have greatly increased our abilities to probe human diseases and to dissect and characterize their heterogeneous phenotypes. Development of impactful therapies requires the redefinition of heterogeneous clinical syndromes/diseases into distinct patient subsets whose underlying disease is driven by a dominant molecular pathogenic pathway. These transformational redefinitions of clinical syndromes enable us to develop and match the appropriate therapies for a given patient so that they derive greatest clinical benefit for their disease.

• My Focus

  Much of my current focus is to ensure that we are at the forefront in discovering new biologies, dissecting the heterogeneous causes of human disease, and thinking about new scientific venues by which these dominant pathways of disease can be attacked.

  Our success requires rigorous scientific investigation into human biology and disease, balanced with innovative basic discovery to reveal novel biologies. Hence, much of my current focus is to ensure that we are at the forefront in discovering new biologies, dissecting the heterogeneous causes of human disease, and thinking about new scientific venues by which these dominant pathways of disease can be attacked.

• Publications

  • Personalizing medicine for autoimmune and inflammatory diseases

    Nature Immunology, 2013, ISSN: 1529-2908

    Chan, Andrew C.; Behrens, Timothy W.

     View on PubMed

  • Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b.

    Journal of Experimental Medicine, 2011, V208, 9, pp 1777-1787. ISSN: 0022-1007, eISSN: 1540-9538

    Niko Föger; André Jencke; Zane Orinska; Kyeong-Hee Lee; Andrew C. Chan; Silvia Bulfone-Paus;

     View on PubMed

  • Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination

    BLOOD, 2011, V118, N3, JUL 21, pp 598-608. ISSN: 0006-4971.

    Nguyen, Xuan Hung; Lang, Philipp A; Lang, Karl S; Adam, Dieter; Fattakhova, Gulnar; Foeger, Niko; Kamal, Mohammad Azhar; Prilla, Patricia; Mathieu, Sabine; Wagner, Christina; Mak, Tak; Chan, Andrew C; Lee, Kyeong Hee

     View on PubMed

  • B cell immunotherapy in autoimmunity - 2010 update.

    Molecular immunology, 2010, ISSN: 1872-9142

    Chan, A.

  • Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue.

    Journal of Biological Chemistry, 2010, ISSN: 0021-9258

    Fiorillo, E.; Orru, V.; Stanford, S.; Liu, Y.; Salek, M.; Rapini, N.; Schenone, A.; Saccucci, P.; Delogu, L.; Angelini, F.; Bitti, M.L.M.; Schmedt, C.; Chan, A.C.; Acuto, O.; Bottini, N.

  • B-cell targeted therapies in human autoimmune diseases: an updated perspective.

    Immunological Reviews, 2010, ISSN: 1600-065X

    Townsend, M.; Monroe, J.; Chan, A.

  • Therapeutic antibodies for autoimmunity and inflammation.

    Nature Reviews Immunology, 2010, ISSN: 1474-1741

    Chan, A.; Carter, P.

  • Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling.

    FEBS Journal, 2009, ISSN: 1742-464X

    Foger, N.; Bulfone-Paus, S.; Chan, A.C.; Lee, K.H.

  • How can we improve the translational landscape for a faster cure of type 1 diabetes?

    Journal of Clinical Investigation, 2009, ISSN: 0021-9738

    vonHerrath, M.; Chan, A.C.

  • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background

    Journal of Immunology, 2009, ISSN: 0022-1767

    Zikherman, J.; Hermiston, M.; Steiner, D.; Hasegawa, K.; Chan, A.; Weiss, A.

• Education
  • Washington University School of Medicine Howard Hughes Medical Institute, Associate Investigator – 2000-2001
  • Washington University School of Medicine Departments of Internal Medicine and Pathology, Associate Professor – 1998-2001
  • Washington University School of Medicine Howard Hughes Medical Institute, Assistant Investigator – 1994-1999
  • Washington University, Barnes Hospital Department of Internal Medicine, Attending Physician – 1994-2001
  • Washington University School of Medicine Departments of Internal Medicine and Pathology, Assistant Professor – 1994-1998
  • University of California, San Francisco Long-Moffitt Hospital, Department of Medicine,, Attending Physician – 1992-1993
  • University of California, San Francisco Department of Medicine, Division of Rheumatology, Assistant Adjunct Professor – 1992-1993
  • University of California, San Francisco Department of Medicine, Division of Rheumatology, Clinical Fellow – 1989-1990
  • Washington University School of Medicine Barnes Hospital, Department of Internal Medicine, Intern and Resident – 1986-1989
  • Washington University School of Medicine, Department of Cellular and Developmental Biology, M.D., Ph.D. – 1986
  • Northwestern University, Department of Chemistry, M.S., B.A. – 1980
  • University of California, San Francisco Department of Medicine, Division of Rheumatology, Associate Clinical Professor – present
• Awards & Honors
  • Special Recognition Award for Mentoring Graduate Students Washington University – 2000
  • Special Recognition Award for Mentoring Graduate Students Washington University – 2000
  • American College of Rheumatology Investigator Award – 1993
  • American College of Rheumatology Investigator Award – 1993
  • American College of Rheumatology Senior Scholar Award – 1991
  • American Foundation of Clinical Research Award – 1991
  • American Foundation of Clinical Research Award – 1991
  • American College of Rheumatology Senior Scholar Award – 1991