/ Scientists

Andrew Peterson

Associate Director, Molecular Biology

POSTDOC MENTOR

"The environment in Research is one in which decision-making is logical, science-based and transparent, and the interactions are collegial. Although these things seem simple and obvious, having them in place allows us to focus on the excitement of science and how to translate biology into effective therapeutics."

24
years at Genentech
17
publications (2010-12)
4
awards & honors

I visited Genentech in 1989 and gave a seminar on CD4 and HIV interactions. That was my first and only direct exposure to the environment here for quite some time but it made enough of a lasting impression that I was very excited when the opportunity to come here as a scientist arose many years later.

Featured Publication

The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.
Sci Signal 2009 Nov 3; 2(95): ra70.
Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS.
View Abstract on PubMed

My Focus

We have primarily been using neural development as our biological paradigm for these investigations, but are beginning to branch out into metabolism. In addition to the largely postdoctoral based efforts of my own lab, I am very involved in a number of projects in Molecular Biology that are also based in murine genetics.
Publications
- Furin-cleaved PCSK9 is active and modulates LDL receptor and serum cholesterol levels
  Journal of Biological Chemistry, 2012, ISSN: 0021-9258
  Lipari, Michael T; Li, Wei; Moran, Paul; Kong-Beltran, Monica; Sai, Tao; Lai, Joyce; Lin, S Jack; Kolumam, Ganesh; Zavala-Solorio, Jose; Izrael-Tomasevic, Anita; Arnott, David; Wang, Jianyong; Peterson, Andrew S; Kirchhofer, Daniel
  View on PubMed
- Calcium-independent inhibition of PCSK9 by affinity-improved variants of the LDL receptor EGF(A) domain
  Journal of Molecular Biology, 2012, ISSN: 0022-2836
  Zhang, Yingnan; Zhou, Lijuan; Kong-Beltran, Monica; Li, Wei; Moran, Paul; Wang, Jianyong; Quan, Clifford; Tom, Jeffrey; Kolumam, Ganesh; Elliott, J. Michael; Skelton, Nicholas J.; Peterson, Andrew S.; Kirchhofer, Daniel
  View on PubMed
- Morphological defects in a novel Rdh10 mutant that has reduced retinoic acid biosynthesis and signaling
  Genesis, 2012, ISSN: 1526-954X
  Ashique, Amir M; May, Scott R; Kane, Maureen A; Folias, Alexandra E; Phamluong, Khanhky; Choe, Youngshik; Napoli, Joseph L; Peterson, Andrew S;
  View on PubMed
- Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
  Developmental Biology, 2012, ISSN: 1095-564X
  Wilson, Deanna G.; Phamluong, Khanhky; Lin, Wei Yu; Barck, Kai; Carano, Richard A.D.; Diehl, Lauri; Peterson, Andrew S.; Martin, Flavius; Solloway, Mark J.
  View on PubMed
- A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
  Nature Cell Biology, 2012, ISSN: 1465-7392
  Chih, Ben; Peterson, Andrew S.; Liu, Peter; Chinn, Yvonne; Hass, Philip E.; Sandoval, Wendy; Chalouni, Cecile; Komuves, Laszlo G.
  View on PubMed
- Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1
  Science Translational Medicine, 2011, ISSN: 1946-6234
  Wu, Ai-Luen; Phamluong, Khanhky; Feng, Bo; Peterson, Andrew S.; Sonoda, Junichiro; Kolumam, Ganesh; Zavala-Solorio, Jose; Kates, Lance; Van Bruggen, Nicholas; Stawicki, Scott; Chen, Yongmei; Kim, Hok Seon; Yansura, Daniel; Wu, Yan; Li, Jun; Marsters, Scot; Filvaroff, Ellen; Li, Li; Leabman, Maya; West, David; Wong, Anne; Stern, Howard; Luis, Elizabeth
  View on PubMed
- Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.
  The Journal of Cell Biology, 2011, ISSN: 0021-9525
  Wilson, Deanna G; Phamluong, Khanhky; Li, Li; Sun, Mei; Cao, Tim C; Liu, Peter S; Modrusan, Zora; Sandoval, Wendy N; Rangell, Linda; Carano, Richard AD; Peterson, Andrew S; Solloway, Mark J
  View on PubMed
- Molecular and cellular contributions of IL-17RC to IL-17 signaling and host defense against fungal infections.
  Cytokine, 2010, ISSN: 1043-4666
  Ho, A.W.; Shen, F.; Conti, H.R.; Patel, N.; Peterson, A.; Hernandez, N.; Kolls, J.K.; Kane, L.; Ouyang, W.; Childs, E.E.; Gaffen, S.
- Circulating biomarkers of MetMAb activity in a phase Ia dose escalating clinical trial.
  Proceedings of the American Association for Cancer Research Annual Meeting, 2010, ISSN: 0197-016X
  Li, C; Nijem, I.; Zheng, J.; Lipkind, M.; Patel, P.; Peterson, A.; Filvaroff, E.; Merchant, M.; Hegde, P.
- IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail.
  Journal of Immunology, 2010, ISSN: 0022-1767
  Ho, A.; Shen, F.; Conti, H.; Patel, N.; Childs, E.; Peterson, A.; Hernandez-Santos, N.; Kolls, J.; Kane, L.; Ouyang, W.; Gaffen, S.
- A mouse knockout library for secreted and transmembrane proteins.
  Nature Biotechnology, 2010, ISSN: 1546-1696
  Tang, T.; Li, L.; Tang, J.; Li, Y.; Lin, W.Y.; Martin, F.; Grant, D.; Solloway, M.; Parker, L.; Ye, W.; Forrest, W.; Ghilardi, N.; Oravecz, T.; Platt, K.; Rice, D.; Hansen, G.; Abuin, A.; Eberhart, D.; Godowski, P.; Holt, K.; Peterson, A.; Zambrowicz, B.; de Sauvage, F.
- The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Cliogenesis.
  Science Signaling, 2009, ISSN: 1937-9145
  Ashique, A.M.; Choe, Y.; Karlen, M.; May, S.R.; Phamluong, K.; Solloway, M.J.; Ericson, J.; Peterson, S.A.
- A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
  Developmental Biology, 2010, ISSN: 1095-564X
  Endoh-Yamagami, S.; Karkar, K.M.; May, S.R.; Cobos, I.; Thwin, M.T.; Long, J.E.; Ashique, A.M.; Zarbalis, K.; Rubenstein, J.L.; Peterson, A.S.
- Retinoic acid from the meninges regulates cortical neuron generation.
  Cell, 2009, ISSN: 0092-8674
  Siegenthaler, J.A.; Ashique, A.M.; Zarbalis, K.; Patterson, K.P.; Hecht, J.H.; Kane, M.A.; Folias, A.E.; Choe, Y.; May, S.R.; Kume, T.; Napoli, J.L.; Peterson, A.S.; Pleasure, S.J.
- The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
  Current Biology, 2009, ISSN: 1879-0445
  Endoh-Yamagami, S.; Evangelista, M.; Wilson, D.; Wen, X.; Theunissen, J.-W.; Phamluong, K.; Davis, M.; Scales, S.J.; Solloway, M.J.; de Sauvage, F.J.; Peterson, A.S.
- Atrophins' emerging roles in development and neurodegenerative disease.
  Cellular and Molecular Life Sciences, 2009, ISSN: 1420-682X
  Shen, Y.; Peterson, A.S.
- Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction
  Science Signaling, 2008, ISSN: 1937-9145
  Evangelista, M.; Lim, T.Y.; Lee, J.; Parker, L.; Ashique, A.; Peterson, A.S.; Ye, W.; Davis, D.P.; de Sauvage, F.J.
Education
- Ernest Gallo Clinic and Research Center, Principal Investigator – 1999-2005
- University of California at San Francisco, California, Department of Neurology Assistant Professor in Residence – 1999-2005
- Duke University Medical Center, Durham North Carolina, Adjunct Assistant Professor of Genetics – 1999-2005
- University of California, San Francisco, California, Department of Physiology, Postdoctoral Fellow – 1994
- Duke University Medical Center, Durham, North Carolina, Department of Genetics and Department of Neurobiology Assistant Professor – 1994-1999
- Harvard University, Genetics, Ph.D – 1988
- University of Washington, Biological Sciences, B.S. – 1982
Awards & Honors
- Basil O'Connor Starter Scholar Award – 1995
- Sandoz Scholar – 1995
- Jane Coffin Childs Postdoctoral Fellowship – 1988
- National Science Foundation Graduate Fellowship – 1982

Andrew Peterson

Associate Director, Molecular Biology

Featured Publication

Furin-cleaved PCSK9 is active and modulates LDL receptor and serum cholesterol levels

Calcium-independent inhibition of PCSK9 by affinity-improved variants of the LDL receptor EGF(A) domain

Morphological defects in a novel Rdh10 mutant that has reduced retinoic acid biosynthesis and signaling

Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain

Metabolic disease: Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1

Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.

Molecular and cellular contributions of IL-17RC to IL-17 signaling and host defense against fungal infections.

Circulating biomarkers of MetMAb activity in a phase Ia dose escalating clinical trial.

IL-17RC Is Required for Immune Signaling via an Extended SEF/IL-17R Signaling Domain in the Cytoplasmic Tail.

A mouse knockout library for secreted and transmembrane proteins.

The Rfx4 Transcription Factor Modulates Shh Signaling by Regional Control of Cliogenesis.

A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.

Retinoic acid from the meninges regulates cortical neuron generation.

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

Atrophins' emerging roles in development and neurodegenerative disease.

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction