Germaine Fuh

Scientist, Antibody Engineering

POSTDOC MENTOR

"The main interest of our lab is to understand how the natural antibody repertoire functions to recognize antigens."

• 28
  years at Genentech
• 10
  publications (2010-12)
• 2
  awards & honors

We based our design on the understanding of how natural antibody repertoire functions to recognize antigens. What we find as the essence of a productive antibody library in turn increases our appreciation for the mechanism of antibody repertoire and adaptive immunity.

• My Focus

  Our aim is to appreciate and dissect the mechanism of action resulting from the interaction of molecules. We apply the knowledge to engineer molecules such as antibodies to have desired properties (affinity/specificity/bispecificity), or to uncover its biological functions.

  The angiogenesis and others. In collaboration with other laboratories, we have been applying protein-engineering methods to study the role of VEGF, BR3 and other related molecules in biological processes.

• Publications

  • Two-in-One antibodies with dual action Fabs

    Current Opinion in Chemical Biology, 2013, ISSN: 1367-5931

    Eigenbrot, Charles; Fuh, Germaine

     View on PubMed

  • Translation levels control multi-spanning membrane protein expression

    PLoS ONE, 2012, ISSN: 1932-6203

    Kim, Hok Seon; Ernst, James A; Brown, Cecilia; Bostrom, Jenny; Fuh, Germaine; Lee, Chingwei V; Huang, Arthur; Vandlen, Richard L; Yansura, Daniel G

     View on PubMed

  • A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies

    Cancer Cell, 18 Oct 2011, v20(4), p.472-86, ISSN: 1878-3686

    Gabriele Schaefer; Lauric Haber; Lisa M. Crocker; Steven Shia; Lily Shao; Donald Dowbenko; Klara Totpal; Anne Wong; Chingwwei V. Lee; Scott Stawicki; Robyn Clark; Carter Fields; Gail D. Lewis Phillips; Rodney A. Prell; Dimitry M. Danilenko; Yvonne Franke; Jean-Philippe Stephan; Jiyoung Hwang; Yan Wu; Jenny Bostrom, Mark X. Sliwkowski; Germaine Fuh; Charles Eigenbrot

     View on PubMed

  • Two-in-One Antibodies.

    Kontermann-RE: Editor; Bispecific Antibodies, 2011, p. 187-198, Publisher: SPRINGER, DOI:10.1007/978-3-642-20910-9_11, ISBN: 978-3-642-20909-3(H).

    Koenig, Patrick; Germaine Fuh

     View on PubMed

  • Effects of anti-VEGF treatment duration on tumor growth, tumor regrowth, and treatment efficacy.

    Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 2010, ISSN: 1078-0432

    Bagri, A.; Berry, L.; Gunter, B.; Singh, M.; Kasman, I.; Damico, L.; Xiang, H.; Schmidt, M.; Fuh, G.; Hollister, B.; Rosen, O.; Plowman, G.

  • Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models.

    Nature Biotechnology, 2010, ISSN: 1546-1696

    Singh, M.; Lima, A.; Molina, R.; Hamilton, P.; Clermont, A.; Devasthali, V.; Thompson, J.; Cheng, J.H.; Bou-Reslan, H.; Ho, C.C.K.; Cao, T., Lee, C., Nannini, M.; Fuh, G.; Carano, R.; Koeppen, H.; Yu, R.; Forrest, W.; Plowman, G.; Johnson, L.

  • Design and construction of synthetic phage-displayed fab libraries.

    Methods in Molecular Biology, 2009, ISSN: 1064-3745

    Bostrom, J.; Fuh, G.

  • Improving antibody binding affinity and specificity for therapeutic development

    , 2009, ISSN:

    Bostrom, J.; Lee, C.V.; Haber, L.; Fuh, G.

  • Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

    Science, 2009, ISSN: 0036-8075

    Bostrom, J.; Yu, S.-F.; Kan, D.; Appleton, B.A.; Lee, C.V.; Billeci, K.; Man, W.; Peale, F.; Ross, S.; Wiesmann, C.; Fuh, G.

  • Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: optimizing methods to quantify vascular changes.

    Investigative Ophthalmology & Visual Science, 2008, ISSN: 0146-0404

    Campa, C; Kasman, I; Ye, W; Lee, W.P; Fuh, G; Ferrara, N.

• Education
  • University of California, San Francisco, M.S. – 1984
  • National Taiwan University, B.S. – 1980
• Awards & Honors
  • Two-in-One antibodies listed by MIT Technology Review as important emerging technology – 2010
  • Ralph Schwall Memorial Award at Genentech –