I joined Genentech in 1992. I have mainly worked on anti-VEGF, VEGF and anti-IgE projects. I found Genentech to have a very intellectually rich environment. I am very impressed by the consistency in excellency across the whole company. I have had the honor of contributing to the success of the anti-VEGF project. We measured activities of anti-VEGF variants in a receptor binding inhibition assay to identify a drug candidate. We also supported preclinical studies. Avastin was approved in 2004 and has helped many cancer patients. My lab also worked on the eye disease indication for anti-VEGF. We developed assays for vitreous and other samples to support preclinical studies, helping lead to approval of Lucentis in 2006. For the anti-IgE project, we developed assays to support preclinical studies. Since its approval in 2003, Xolair has helped many asthma patients to breath better.

• My Focus

  The focus of my lab is mainly on developing assays for antibodies (assays for measuring relative binding affinities for antigens and Fc receptors, for measuring therapeutic antibodies in serum or plasma, for detecting anti-drug antibodies following drug administration, etc.) and developing ultra sensitive assays to measure endogenous proteins.

  Currently, we are implementing the ultra-sensitive immuno-PCR assay method to support biomarker efforts. Recently, we started developing assays for siRNA-based therapeutics.

• Publications

  • Predictive Impact of Circulating Vascular Endothelial Growth Factor in 4 Phase III Trials Evaluating Bevacizumab

    Clinical Cancer Research, 2012, ISSN: 1078-0432

    Hegde, Priti S; Jubb, Adrian M; Chen, Dafeng; Li, Nicole F; Meng, Gloria; Bernaards, Coen; Elliott, Rebecca; Scherer, Stefan; Chen, Daniel S

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  • Real-time quantification of antibody-siRNA conjugate in serum by antigen-capture RT-PCR

    Analytical Biochemistry, 2012, ISSN: 0003-2697

    Tan, Martha; Vernes, Jean-Michel; Chan, Joyce; Cuellar, Trinna L; Asundi, Aarati; Nelson, Christopher; Yip, Victor; Shen, Ben; Vandlen, Richard; Siebel, Christian; Gloria Meng, Y

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  • Induction of Bv8 Expression by granulocyte colony-stimulating factor in CD11b + Gr1 + cells: Key role of Stat3 signaling

    Journal of Biological Chemistry, 2012, ISSN: 0021-9258

    Qu, Xueping; Zhuang, Guanglei; Yu, Lanlan; Meng, Gloria; Ferrara, Napoleone

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  • Engineering upper hinge improves stability and effector function of a human IgG1

    Journal of Biological Chemistry, 2012, ISSN: 0021-9258

    Yan, Boxu; Boyd, Daniel; Kaschak, Timothy; Tsukuda, Joni; Shen, Amy; Lin, Yuwen; Chung, Shan; Gupta, Priyanka; Kamath, Amrita; Wong, Anne; Vernes, Jean-Michel; Meng, Gloria Y.; Totpal, Klara; Schaefer, Gabriele; Jiang, Guoying; Nogal, Bartek; Emery, Craig; Vanderlaan, Martin; Carter, Paul; Harris, Reed; Amanullah, Ashraf

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  • Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

    mAbs, 2012, ISSN: 1942-0862

    Deng, Rong; Lutman, Jeff; Iyer, Suhasini; Theil, Frank-Peter; Fielder, Paul J.; Prabhu, Saileta; Meng, Y. Gloria; Hoyte, Kwame; Lu, Yanmei; DeForge, Laura E.

     View on PubMed

  • The Development of Peptide-Based Tools for the Analysis of Angiogenesis

    Chemistry & biology, {Chem-Biol}, 29 Jul 2011, vol. 18, no. 7, p. 839-45, ISSN: 1879-1301.

    Fedorova, Anna; Zobel, Kerry; Gill, Herman S; Ogasawara, Annie; Flores, Judith E; Tinianow, Jeff N; Vanderbilt, Alexander N; Wu, Ping; Meng, Y Gloria; Williams, Simon P; Wiesmann, Christian; Murray, Jeremy; Marik, Jan; Deshayes, Kurt

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  • Identification of IgG(1) variants with increased affinity to Fcγ RIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays.

    Journal of Immunological Methods, 2010, ISSN: 1872-7905

    Lu, Y.; Vernes, J.M.; Chiang, N.; Ou, Q.; Ding, J.; Adams, C.; Hong, K.; Truong, B.T.; Ng, D.; Shen, A.; Nakamura, G.; Gong, Q.; Presta, L.G.; Beresini, M.; Kelley, B.; Lowman, H.; Wong, W.; Meng, Y.G.

  • Inaugural Article: Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes.

    Proceedings of the National Academy of Sciences, 2010, ISSN: 1091-6490

    Kowanetz, M.; Wu, X.; Lee, J.; Tan, M.; Hagenbeek, T.; Qu, X.; Yu, L.; Ross, J.; Korsisaari, N.; Cao, T.; Bou, R.H.; Kallop, D.; Weimer, R.; Ludlam, M.J.; Kaminker, J.S.; Modrusan, Z.; van Bruggen, N.; Peale, F.V.; Carano, R.; Meng, Y.G.; Ferrara, N.

  • Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer.

    Cancer Research, 2010, ISSN: 1538-7445

    Junttila, T.; Parsons, K.; Olsson, C.; Lu, Y.; Xin, Y.; Theriault, J.; Crocker, L.; Pabonan, O.; Baginski, T.; Meng, G.; Totpal, K.; Kelley, R.; Sliwkowski, M.

  • A Therapeutic Anti-VEGF Antibody with Increased Potency Independent of Pharmacokinetic Half-life.

    Cancer Research, 2010, ISSN: 1538-7445

    Yeung, Y.A.; Wu, X.; Reyes, A.E. 2nd.; Vernes, J.M.; Lien, S.; Lowe, J.; Maia, M.; Forrest, W.F.; Meng, Y.G.; Damico, L.A.; Ferrara, N.; Lowman, H.B.

  • Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration.

    mAbs, 2009, ISSN: 1942-0862

    Lu, Y.; Xiang, H.; Liu, P.; Tong, R.R.; Watts, R.J.; Koch, A.W.; Sandoval, W.N.; Damico, L.A.; Wong, W.L.; Meng, Y.G.

  • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models.

    Proc. Natl. Acad. Sci., USA, 2009, ISSN: 1091-6490

    Shojaei, F.; Wu, X.; Qu, X.; Kowanetz, M.; Yu, L.; Tan, M.; Meng, Y.G.; Ferrara, N.

  • Characterization and regulation of Bv8 in human blood cells.

    Clinical Cancer Research, 2009, ISSN: 1078-0432

    Zhong, C.; Qu, X.; Tan, M.; Meng, Y.G.; Ferrara, N.

• Education
  • University of California, Berkeley, Department of Chemistry, Postdoctoral Fellow – 1984
  • Columbia University, New York City, Chemistry with emphasis in Biochemistry, Ph.D. – 1980
  • National Tsing-Hua University, Hsing-Tsu, Taiwan, ROC, Chemistry, B.S. – 1974