I joined Genentech in 1999 after two years at another biotech company, Genetics Institute (now merged with Wyeth Pharmaceuticals). I chose to join biotech in order to do research that can more directly benefit patients. Genentech has certainly been an exciting place to do research. There are so many opportunities for pursuing new ideas.

• My Focus

  I have a joint appointment with the Immunology Department and have become involved with many of their research efforts, from early discovery of novel genes, microarray analysis to identifying gene signatures in immune cell subsets and disease biopsies. Most recently, we have been using human genetics to identify key risk genes for asthma and Crohn's disease. I have gotten the most satisfaction from contributing to several late-stage research projects that have moved into Development and will soon be in clinical trials.

• Publications

  • Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q.

    PloS one, {PLoS-ONE}, 2011 (epub: 12 Oct 2011), vol. 6, no. 10, p. e25038, ISSN: 1932-6203.

    Pidasheva, Svetlana; Trifari, Sara; Phillips, Anne; Hackney, Jason A; Ma, Yan; Smith, Ashley; Sohn, Sue J; Spits, Hergen; Little, Randall D; Behrens, Timothy W; Honigberg, Lee; Ghilardi, Nico; Clark, Hilary F

     View on PubMed

  • Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model

    American Journal of Pathology, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1525-2191.

    Abbas, Alexander R; Jackman, Janet K; Bullens, Sherron L; Davis, Sarah M; Choy, David F; Fedorowicz, Grazyna; Tan, Martha; Truong, Bao Tran; Gloria, Meng Y; Diehl, Lauri; Miller, Lisa A; Schelegle, Edward S; Hyde, Dallas M; Clark, Hilary F; Modrusan, Zora; Arron, Joseph R; Wu, Lawren C

     View on PubMed

  • Gene Expression Patterns of Th2 Inflammation and Intercellular Communication in Asthmatic Airways.

    Journal of Immunology, 2010, ISSN: 1550-6606

    Choy, D.F.; Modrek, B.; Abbas, A.R.; Kummerfeld, S.; Clark, H.F.; Wu, L.C.; Fedorowicz, G.; Modrusan, Z.; Fahy, J.V.; Woodruff, P.G.; Arron, J.R.

  • Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

    Nature Genetics, 2010, ISSN: 1546-1718

    Ferreira, R.; Pan-Hammarstroem, Q.; Graham, R.; Gateva, V.; Fontan, G.; Lee, A.; Ortmann, W.; Urcelay, E.; Fernandez-Arquero, M.; Nunez, C.; Jorgensen, G.; Ludviksson, B.; Koskinen, S.; Haimila, K.; Clark, H.; Klareskog, L.; Gregersen, P.; Behrens, T.; Hammarstroem, L.

  • Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1.

    Journal of Experimental Medicine, 2010, ISSN: 1540-9538

    Xi, H.; Katschke, K.J. Jr.; Helmy, K.Y.; Wark, P.A.; Kljavin, N.; Clark, H.; Eastham-Anderson, J.; Shek, T.; Roose-Girma, M.; Ghilardi, N.; van Lookeren Campagne, M.

  • The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

    Nature Immunology, 2009, ISSN: 1529-2916

    Yu, X.; Harden, K.; Gonzalez, L.C.; Francesco, M.; Chiang, E.; Irving, B.; Tom, I.; Ivelja, S.; Refino, C.J.; Clark, H.; Eaton, D.; Grogan, J.L.

• Education
  • Harvard Medical School, Postdoctoral Research – 1994
  • University of California at Berkeley, Ph.D. – 1993
  • San Francisco State University, B.S. – 1988
  • University of San Francisco, B.S. – 1982
• Awards & Honors
  • Phi Beta Kappa –
  • National Science Foundation Honorable Mention –
  • B.S. Summa Cum Laude –