Isidro Hötzel

Scientist, Antibody Engineering

POSTDOC MENTOR

• 9
  years at Genentech
• 2
  publications (2010-12)

The main interest of my lab is the development of new technologies for antibody discovery with mammalian multispan membrane proteins.

Multispan membrane proteins present significant technical challenges to biochemical and structural studies as well as to the application of the powerful combinatorial biology tools for antibody discovery that have proved very successful with soluble protein targets.

Our aim is to develop new tools and methodologies to apply phage display and other combinatorial biology procedures to multispan proteins to overcome and bypass the challenges that these proteins present to antibody discovery. An exciting aspect of this work is the opportunity for extensive collaborations with scientists in the molecular biology, oncology, infectious disease, structural biology, protein engineering and other groups within

• My Focus

  An area of interest is the development of new technologies to improve the efficiency of discovery and optimization of antibodies for therapeutic and research applications using phage display and other combinatorial biology methods.

• Publications

  • Molecular basis for negative regulation of the glucagon receptor

    Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

    Koth, Christopher M; Murray, Jeremy M; Mukund, Susmith; Madjidi, Azadeh; Minn, Alexandra; Clarke, Holly J; Wong, Terence; Chiang, Vicki; Luis, Elizabeth; Estevez, Alberto; Rondon, Jesus; Zhang, Yingnan; Hötzel, Isidro; Allan, Bernard B

     View on PubMed

  • Efficient production of antibodies against a mammalian integral membrane protein by phage display

    Protein Engineering, Design and Selection, Sep 2011, v24(9), p.679-689, ISSN: 1741-0126, eISSN: 1741-0134

    Hötzel, Isidro; Chiang, Vicki; Diao, Jingyu; Pantua, Homer; Maun, Henry R.; Kapadia, Sharookh B.

     View on PubMed

• Education
  • Washington State University, Department of Veterinary Microbiology and Pathology, Postdoctoral Fellow – 2003
  • Washington State University, Department of Veterinary Microbiology and Pathology, Ph.D. – 1997
  • Universidade Federal do Rio Grande do Sul, Brazil, DVM – 1992