Joe Arron

Senior Scientist, ITGR Diagnostics Discovery

POSTDOC MENTOR

"My department's motto is "the right drug for the right patient."

• 6
  years at Genentech
• 14
  publications (2010-12)
• 1
  awards & honors

I direct a research group devoted to investigating disease heterogeneity and biomarker discovery in allergic and respiratory diseases. We have recently shown that a subset of asthma patients exhibits excessive type 2 airway inflammation and we identified non-invasive biomarkers of this asthma subtype. We are currently working to further optimize these biomarkers and identify additional mechanisms and biomarkers in the subtype ofother asthma subtypes.

• My Focus

  My department's motto is "the right drug for the right patient." Highly targeted molecular therapeutics have significant promise, but only if those targets are relevant in the patients being treated. Understanding the heterogeneity of complex human diseases on a molecular level is paramount to delivering personalized therapy and discovering new therapeutic pathways. Therefore, we are studying the molecular, pathophysiological, and clinical bases of human diseases, using samples from observational studies and cell culture models to develop hypotheses that we can then test in interventional clinical trials. Post hoc analyses of clinical trial samples and data often lead to new hypotheses to test in future studies in a feed-forward virtuous cycle.

• Publications

  • Redefining approaches to asthma: developing targeted biologic therapies

    Advances in Pharmacology, 2013, ISSN: 1054-3589

    Arron, Joseph R; Scheerens, Heleen; Matthews, John G

     View on PubMed

  • Airway epithelial miRNA expression is altered in asthma

    American Journal of Respiratory and Critical Care Medicine, 2012, ISSN: 1073-449X

    Solberg, Owen D.; Ostrin, Edwin J.; Love, Michael I.; Peng, Jeffrey C.; Bhakta, Nirav R.; Hou, Lydia; Nguyen, Christine; Solon, Margaret; Nguyen, Cindy; Barczak, Andrea J.; Zlock, Lorna T.; Blagev, Denitza P.; Finkbeiner, Walter E.; Ansel, K. Mark; Arron, Joseph R.; Erle, David J.; Woodruff, Prescott G.

     View on PubMed

  • Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

    Journal of Allergy and Clinical Immunology, 2012, ISSN:

    Guiquan Jia; Richard W. Erickson; David F. Choy; Sofia Mosesova; Lawren C. Wu; Owen D. Solberg; Aarti Shikotra; Richard Carter; Séverine Audusseau; Qutayba Hamid; Peter Bradding; John V. Fahy; Prescott G. Woodruff; Jeffrey M. Harris; Joseph R. Arron

     View on PubMed

  • Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation

    Journal of Allergy and Clinical Immunology, 2012, ISSN: 0091-6749

    Choy, David F; Hsu, Daniel K; Seshasayee, Dhaya; Fung, Maxwell A; Modrusan, Zora; Martin, Flavius; Liu, Fu-Tong; Arron, Joseph R

     View on PubMed

  • Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma

    Thorax, 2012, ISSN:

    Butler, Claire A; McQuaid, Stephen; Taggart, Cliff C; Weldon, Sinead; Carter, Richard; Skibinski, Grzegorz; Warke, Timothy J; Choy, David F; McGarvey, Lorcan P; Bradding, Peter; Arron, Joe R; Heaney, Liam G;

     View on PubMed

  • Lebrikizumab Treatment in Adults with Asthma

    The New England journal of medicine, {N-Engl-J-Med}, 3 Aug 2011 (epub: 3 8 2011), ISSN: 1533-4406.

    Corren, Jonathan; Lemanske, Robert F; Hanania, Nicola A; Korenblat, Phillip E; Parsey, Merdad V; Arron, Joseph R; Harris, Jeffrey M; Scheerens, Heleen; Wu, Lawren C; Su, Zheng; Mosesova, Sofia; Eisner, Mark D; Bohen, Sean P; Matthews, John G

     View on PubMed

  • Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model

    American Journal of Pathology, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1525-2191.

    Abbas, Alexander R; Jackman, Janet K; Bullens, Sherron L; Davis, Sarah M; Choy, David F; Fedorowicz, Grazyna; Tan, Martha; Truong, Bao Tran; Gloria, Meng Y; Diehl, Lauri; Miller, Lisa A; Schelegle, Edward S; Hyde, Dallas M; Clark, Hilary F; Modrusan, Zora; Arron, Joseph R; Wu, Lawren C

     View on PubMed

  • Gene Expression Patterns of Th2 Inflammation and Intercellular Communication in Asthmatic Airways.

    Journal of Immunology, 2010, ISSN: 1550-6606

    Choy, D.F.; Modrek, B.; Abbas, A.R.; Kummerfeld, S.; Clark, H.F.; Wu, L.C.; Fedorowicz, G.; Modrusan, Z.; Fahy, J.V.; Woodruff, P.G.; Arron, J.R.

  • Comparative Gene Expression Analyses Reveal Differential Helper T cell Polarization in Atopic Dermatitis, Contact Dermatitis, and Psoriasis.

    Journal of Allergy and Clinical Immunology, 2010, ISSN: 0091-6749

    Arron, J.R.; Choy, D.F.; Seshasayee, D.; Martin, F.; Hsu, D.K.; Liu, F.

  • Molecular Th2 Phenotypes of Asthma: New Biomarker or NO?

    American Journal of Respiratory & Critical Care Medicine, 2010, ISSN: 1073-449X

    Woodruff, P.G.; Arron, J.R.; Fahy, J.V.

  • Promising bone-related targets for rheumatoid arthritis therapy.

    Nature Reviews Rheumatology, 2009, ISSN: 1759-4790

    Choi, Y.; Arron, J.R.; Townsend, M.J.

  • Monitoring ocular drug therapy by analysis of aqueous samples.

    Ophthalmology, 2009, ISSN: 0161-6420

    Campochiaro, P.A.; Choy, D.F.; Do, D.V.; Hafiz, G.; Shah, S.M.; Nguyen, Q.D.; Rubio, R.; Arron, J.R.

  • T-helper type 2-driven inflammation defines major subphenotypes of asthma.

    American Journal of Respiratory and Critical Care Medicine, 2009, ISSN: 1073-449X

    Woodruff, P.G.; Modrek, B.; Choy, D.F.; Jia, G.Q.; Abbas, A.R.; Ellwanger, A.; Arron, J.R.; Koth, L.L.; Fahy, J.V.

  • Breaking into bone biology

    Nature Medicine, 2009, ISSN:

    Choi, Y.; Walsh, M.C.; Arron, J.R.

• Education
  • Stanford University School of Medicine, Postdoctoral scholar – 2006
  • Weill Medical College of Cornell University, M.D. – 2003
  • The Rockefeller University, Ph.D. – 2002
  • Princeton University, A.B. – 1996
• Awards & Honors
  • Compositions and Methods for Treating and Diagnosing Asthma – 2009