Lauri Diehl

Senior Scientist, Pathology

POSTDOC MENTOR

"Like most scientists, I find a lot of satisfaction in getting even one small step closer to understanding how biologic processes work. But what really pushes me to work harder, think more broadly, and try new things is the possibility that our research could result in better outcomes for patients suffering from severe chronic diseases."

• 11
  years at Genentech
• 14
  publications (2010-12)
• 4
  awards & honors

Genentech was a company which captured my imagination during my residency and later research training. Genentech scientists were publishing cutting-edge research results, but were also integrated into an active biotechnology company with the goal of translating scientific discovery into practical therapeutics. I thought taking an idea from bench research to clinical medicine would be an exciting and rewarding scientific opportunity.

I joined the research pathology group at Genentech in late 2002. Every day presents new challenges and opportunities. I've been a part of collaborative research programs where drugs are now moving into clinical trials, and I've had the chance to pursue new research ideas of my own. I still find the possibility of translating basic scientific research into improved clinical benefit to be the most compelling part of my job.

• My Focus

  My laboratory research focuses on two areas - understanding patient heterogeneity and understanding the role of intestinal epithelial cells in IBD pathogenesis. The IBD heterogeneity studies involve collaborations with academic gastroenterology centers, and we work to identify patient/disease characteristics which may predict disease course or responsiveness to particular therapeutic agents.

  Our discovery research efforts focus on intestinal epithelial cell interaction with the mucosal immune system. We are particularly interested in how intestinal epithelial cells may initiate or amplify mucosal inflammation in IBD and are studying proteins which are differentially regulated under inflammatory conditions.

• Publications

  • An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides

    Disease Models & Mechanisms, 2013, ISSN: 1754-8403

    Kozlowski, Cleopatra; Jeet, Surinder; Beyer, Joseph; Guerrero, Steve; Lesch, Justin; Wang, Xiaoting; Devoss, Jason; Diehl, Lauri

     View on PubMed

  • CRIg mediates early Kupffer cell responses to adenovirus

    Journal of Leukocyte Biology, 2012, ISSN: 0741-5400

    He, Jeannie Q; Katschke, Kenneth J; Gribling, Peter; Suto, Eric; Lee, Wyne P; Diehl, Lauri; Eastham-Anderson, Jeffrey; Ponakala, Anusha; Komuves, Laszlo; Egen, Jackson G; van Lookeren Campagne, Menno

     View on PubMed

  • Activation of the Alternative Complement Pathway in Vitreous is Controlled by Genetics in Age-related Macular Degeneration

    Investigative Ophthalmology & Visual Science, 2012, ISSN: 0146-0404

    Loyet, Kelly M; Deforge, Laura E; Katschke, Kenneth J; Diehl, Lauri; Graham, Robert R; Pao, Lily; Sturgeon, Lizette; Lewin-Koh, Sock-Cheng; Hollyfield, Joe G; van Lookeren Campagne, Menno

     View on PubMed

  • Hepatitis C Virus Induces Epidermal Growth Factor Receptor Activation via CD81 Binding for Viral Internalization and Entry

    Journal of Virology, 2012, ISSN: 0022-538X

    Diao, Jingyu; Pantua, Homer; Ngu, Hai; Komuves, Laszlo; Diehl, Lauri; Schaefer, Gabriele; Kapadia, Sharookh B.

     View on PubMed

  • Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning

    Developmental Biology, 2012, ISSN: 1095-564X

    Wilson, Deanna G.; Phamluong, Khanhky; Lin, Wei Yu; Barck, Kai; Carano, Richard A.D.; Diehl, Lauri; Peterson, Andrew S.; Martin, Flavius; Solloway, Mark J.

     View on PubMed

  • Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis

    Science, 6 Jan 2012, v335(6064), p89-92, ISSN: 0036-8075, eISSN: 1095-9203

    Hsu, Chia-Lin; Lin, Weiyu; Seshasayee, Dhaya; Chen, Yung-Hsiang; Ding, Xiao; Lin, Zhonghua; Suto, Eric; Huang, Zhiyu; Lee, Wyne P; Park, Hyunjoo; Xu, Min; Sun, Mei; Rangell, Linda; Lutman, Jeff L; Ulufatu, Sheila; Stefanich, Eric; Chalouni, Cecile; Sagolla, Meredith; Diehl, Lauri; Fielder, Paul; Dean, Brian; Balazs, Mercedesz; Martin, Flavius

     View on PubMed

  • IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.

    Nature Immunology, 12 Oct 2011, ISSN: 1529-2916.

    Ramirez, Carrozzi Vladimir; Sambandam, Arivazhagan; Luis, Elizabeth; Lin, Zhongua; Jeet, Surinder; Lesch, Justin; Hackney, Jason; Kim, Janice; Zhou, Meijuan; Lai, Joyce; Modrusan, Zora; Sai, Tao; Lee, Wyne; Xu, Min; Caplazi, Patrick; Diehl, Lauri; de Voss, Jason; Balazs, Mercedesz; Gonzalez, Lino Jr; Singh, Harinder; Ouyang, Wenjun; Pappu, Rajita

     View on PubMed

  • IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

    Nature Immunology, 28 Aug 2011 (epub: 28 8 2011), ISSN: 1529-2916.

    Ota, Naruhisa; Wong, Kit; Valdez, Patricia A; Zheng, Yan; Crellin, Natasha K; Diehl, Lauri; Ouyang, Wenjun

     View on PubMed

  • Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model

    American Journal of Pathology, 2 Aug 2011 (epub: 2 8 2011), ISSN: 1525-2191.

    Abbas, Alexander R; Jackman, Janet K; Bullens, Sherron L; Davis, Sarah M; Choy, David F; Fedorowicz, Grazyna; Tan, Martha; Truong, Bao Tran; Gloria, Meng Y; Diehl, Lauri; Miller, Lisa A; Schelegle, Edward S; Hyde, Dallas M; Clark, Hilary F; Modrusan, Zora; Arron, Joseph R; Wu, Lawren C

     View on PubMed

  • IL-27 promotes T cell-dependent colitis through multiple mechanisms.

    Journal of Experimental Medicine, 2010, ISSN: 1540-9538

    Cox, J.H.; Kljavin, N.M.; Ramamoorthi, N.; Diehl, L.; Batten, M.; Ghilardi, N.

  • Characterization of Intestinal Gene Expression Profiles in Crohn's Disease by Genome-wide Microarray Analysis.

    Inflammatory Bowel Diseases, 2010, ISSN: 1078-0998

    Noble, C.; Abbas, A.R.; Lees, C.W.; Cornelius, J.; Toy, K.; Modrusan, Z.; Clark, H.F.; Arnott, I.D.; Penman, I.D.; Satsangi, J.; Diehl, L.

  • Host-detrimental role of Esx-1-mediated inflammasome activation in mycobacterial infection.

    PLoS Pathogens, 2010, ISSN: 1553-7374

    Carlsson, F.; Kim, J.; Dumitru, C.; Barck, K.; Carano, R.; Sun, M.; Diehl, L.; Brown, E.

  • Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation.

    Journal of Biological Chemistry, 2009, ISSN: 0021-9258

    Li, B.; Xi, H.K.; Diehl, L.; Lee, W.P.; Sturgeon, L.; Chinn, J.; DeForge, L.; Kelley, R.F.; Wiesmann, C.; Campagne, M.V.; Sidhu, S.S.

  • Targeted depletion of lymphotoxin-α-expressing T_H1 and T_H17 cells inhibits autoimmune disease.

    Nature Medicine, 2009, ISSN: 1078-8956

    Chiang, E.Y.; Kolumam, G.A.; Yu, X.; Francesco, M.; Ivelja, S.; Peng, I.; Gribling, P.; Shu, J.; Lee, W.P.; Refino, C.J.; Balazs, M.; Paler-Martinez, A.; Nguyen, A.; Young, J.; Barck, K.H.; Carano, R.A.D.; Ferrando, R.; Diehl, L.; Chatterjea, D.; Grogan, J.L.

• Education
  • Stanford University, California, Postdoctoral Fellow – 1998
  • Colorado State University, Colorado, Ph.D. – 1995
  • Kansas State University, Kansas, D.V.M. – 1988
  • Kansas State University, Kansas, B.S. – 1986
• Awards & Honors
  • Solvay Resident Research Award – 1995
  • Gamma Sigma Delta, Agriculture Honor Society – 1987
  • Phi Zeta, Veterinary Honor Society – 1987
  • Putnam Scholar – 1985