Minhong Yan

Senior Scientist, Molecular Biology

POSTDOC MENTOR

"It is extremely satisfying that our work has the potential to significantly impact patients' life."

• 16
  years at Genentech
• 6
  publications (2010-12)

I came to Genentech as a postdoc with Vishva Dixit in 1997 to investigate signaling pathways regulating cell survival and death. Genentech offers rich opportunities to expand my research horizon to diverse areas ranging from cell signaling to B cell biology to vascular biology.

• My Focus

  We are interested in signaling pathways that regulate vascular processes during vascular development and tumor angiogenesis. Research activities range from uncovering novel signaling components, investigating the molecular and cellular machinery that drives the vasculature alteration upon signaling disruption, exploring vascular biology using mouse models, to developing therapeutic strategies.

• Publications

  • Blockade of individual notch ligands and receptors controls graft-versus-host disease

    Journal of Clinical Investigation, 2013, ISSN: 0021-9738

    Tran, Ivy T.; Sandy, Ashley R.; Carulli, Alexis J.; Ebens, Christen; Chung, Jooho; Shan, Gloria T.; Radojcic, Vedran; Friedman, Ann; Gridley, Thomas; Shelton, Amy; Reddy, Pavan; Samuelson, Linda C.; Yan, Minhong; Siebel, Christian W.; Maillard, Ivan

     View on PubMed

  • Therapeutic promise and challenges of targeting DLL4/NOTCH1

    Vascular Cell, 8 Aug 2011, v3, p17, ISSN: 2045-824X.

    Yan, Minhong

     View on PubMed

  • The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development.

    Blood, {Blood}, 23 Jun 2011 (epub: 23 6 2011), ISSN: 1528-0020.

    Niessen, Kyle; Zhang, Gu; Ridgway, John Brady; Chen, Hao; Kolumam, Ganesh; Siebel, Christian W; Yan, Minhong

     View on PubMed

  • Therapeutic antibody targeting of individual Notch receptors.

    Nature, 2010, ISSN: 1476-4687

    Wu, Y.; Cain-Hom, C.; Choy, L.; Hagenbeek, T.J.; de Leon, G.P.; Chen, Y.; Finkle, D.; Venook, R.; Wu, X.; Ridgway, J.; Schahin-Reed, D.; Dow, G.J.; Shelton, A.; Stawicki, S.; Watts, R.J.; Zhang, J.; Choy, R.; Howard, P.; Kadyk, L.; Yan, M.; Zha, J.; Callahan, C.A.; Hymowitz, S.G.; Siebel, C.W.

  • ALK1 signaling regulates early postnatal lymphatic vessel development.

    Blood, 2010, ISSN: 1528-0020

    Niessen, K.; Zhangm, G.; Ridgway, J.B.; Chen, H.; Yan, M.

  • Chronic DLL4 blockade induces vascular neoplasms.

    Nature, 2010, ISSN: 1476-4687

    Yan, M.; Callahan, C.A.; Beyer, J.C.; Allamneni, K.P.; Zhang, G.; Ridgway, J.B.; Niessen, K.; Plowman, G.D.

• Education
  • Case Western Reserve University, Molecular and Cellular Biology, Ph.D – 1997
  • Shanghai Institute of Biochemistry, Chinese Academy of Science, M.S. – 1991
  • Eastern China University of Technology, Biochemistry, B.S. – 1988