Richard Carano

Senior Scientist, Biomedical Imaging

POSTDOC MENTOR

"Working at Genentech has offered me the rewarding opportunity to not only contribute to the development of new imaging diagnostics, but also to contribute in the development of successful treatments for diseases."

• 13
  years at Genentech
• 7
  publications (2010-12)
• 3
  awards & honors

I joined Genentech's Biomedical Imaging Group in 2000. My educational background is in biomedical and electrical engineering with a focus on medical imaging and image analysis. Prior to joining Genentech, I had worked in both academia and industry developing imaging methods to study disease and monitor therapy. I chose to come to Genentech because it offers the exciting opportunity to develop novel imaging methods in tandem with the development of novel therapeutics, where imaging can be used not only to assess the efficacy of the compound, but also to provide insight into the mode of action of the drug.

Genentech provides the resources and the collaborative environment needed to tackle such tasks in an efficient and thorough manner. Since joining Genentech, my research efforts have been directed toward the development of micro-computed tomography, MRI, and ultrasound imaging techniques to quantify structural and physiological parameters. Our research efforts focus on developing the appropriate imaging and analysis methodologies that will best answer the biological question we are addressing.

• My Focus

  We have been developing a suite of imaging methods and analysis techniques to quantify tumor angiogenesis. These endpoints include micro-ct angiographic techniques to quantify vessel structures and dynamic imaging techniques (MRI and Ultrasound) for studying tumor permeability and perfusion. We also have been working on multispectral MRI methods to identify viable tumor tissue and quantify the pathophysiology of the viable tumor.

  The current research focus of our lab includes several areas. We have been developing a suite of imaging methods and analysis techniques to quantify tumor angiogenesis. These endpoints include micro-ct angiographic techniques to quantify vessel structures and dynamic imaging techniques (MRI and Ultrasound) for studying tumor permeability and perfusion. We also have been working on multispectral MRI methods to identify viable tumor tissue and quantify the pathophysiology of the viable tumor. These methods attempt to address the high degree of structural and physiological heterogeneity seen within solid tumors. Other areas of research include employing imaging to quantify bone loss in models of rheumatoid arthritis and inflammation in models of multiple sclerosis.

• Publications

  • Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia

    PLoS ONE, 2013, ISSN: 1932-6203

    Wu, Ai-Luen; Feng, Bo; Chen, Mark Z; Kolumam, Ganesh; Zavala-Solorio, Jose; Wyatt, Shelby K; Gandham, Vineela D; Carano, Richard A D; Sonoda, Junichiro

     View on PubMed

  • Blocking NRG1 and Other Ligand-Mediated Her4 Signaling Enhances the Magnitude and Duration of the Chemotherapeutic Response of Non-Small Cell Lung Cancer

    Science Translational Medicine, 2013, ISSN: 1946-6234

    Hegde, Ganapati V; de la Cruz, Cecile C; Chiu, Cecilia; Alag, Navneet; Schaefer, Gabriele; Crocker, Lisa; Ross, Sarajane; Goldenberg, David; Merchant, Mark; Tien, Janet; Shao, Lily; Roth, Leslie; Tsai, Siao-Ping; Stawicki, Scott; Jin, Zhaoyu; Wyatt, Shelby K; Carano, Richard A D; Zheng, Yanyan; Sweet-Cordero, E Alejandro; Wu, Yan; Jackson, Erica L

     View on PubMed

  • Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumor models

    Journal of Pathology, 2012, ISSN:

    Singh, Mallika; Couto, Suzana S; Forrest, William F; Lima, Anthony; Cheng, Jason H; Molina, Rafael; Long, Jason E; Hamilton, Patricia; McNutt, Angela; Kasman, Ian; Nannini, Michelle A; Reslan, Hani Bou; Cao, Tim C; Ho, Calvin C. K; Barck, Kai H; Carano, Richard A. D; Foreman, Oded; Eastham-Anderson, Jeffrey; Jubb, Adrian M; Ferrara, Napoleone; Johnson, Leisa;

     View on PubMed

  • Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning

    Developmental Biology, 2012, ISSN: 1095-564X

    Wilson, Deanna G.; Phamluong, Khanhky; Lin, Wei Yu; Barck, Kai; Carano, Richard A.D.; Diehl, Lauri; Peterson, Andrew S.; Martin, Flavius; Solloway, Mark J.

     View on PubMed

  • Death Receptors DR6 and TROY Regulate Brain Vascular Development

    Developmental cell, 2012, ISSN: 1534-5807

    Tam, Stephen J; Richmond, David L; Kaminker, Joshua S; Modrusan, Zora; Martin-McNulty, Baby; Cao, Tim C; Weimer, Robby M; Carano, Richard A D; van Bruggen, Nick; Watts, Ryan J

  • USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma.

    Cell, 16 Sep 2011, vol. 146, no. 6, p. 918-30, ISSN: 1097-4172.

    Williams, Samuel A; Maecker, Heather L; French, Dorothy M; Liu, Jinfeng; Gregg, Andrew; Silverstein, Leah B; Cao, Tim C; Carano, Richard A D; Dixit, Vishva M

     View on PubMed

  • Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.

    The Journal of Cell Biology, 2011, ISSN: 0021-9525

    Wilson, Deanna G; Phamluong, Khanhky; Li, Li; Sun, Mei; Cao, Tim C; Liu, Peter S; Modrusan, Zora; Sandoval, Wendy N; Rangell, Linda; Carano, Richard AD; Peterson, Andrew S; Solloway, Mark J

     View on PubMed

• Education
  • Worcester Polytechnic Institute, Biomedical Engineering, Ph.D. – 1998
  • University of California, Davis, Electrical Engineering and Computer Science, M.S. – 1985
  • Rutgers University, Electrical Engineering, B.S. – 1981
• Awards & Honors
  • Eta Kappa Nu, National Electrical Engineering Honor Society –
  • Potvin Award: Outstanding Biomedical Graduate Student (WPI) –
  • Tau Beta Pi, National Engineering Honor Society –