Shiva Malek

Associate Director, Biochemical and Cellular Pharmacology

POSTDOC MENTOR

"I am inspired by cancer survivors and their ability to face the unknown with courage, strength, and a will to live. The pictures and stories of patients whose lives we have positively impacted is a source of motivation for me."

• 7
  years at Genentech
• 5
  publications (2010-12)
• 6
  awards & honors

I came to Genentech in 2006 to help build the growing small molecule drug discovery group, having spent a number of years at smaller biotechnology companies including Vertex Pharmaceuticals and Exelixis.

I am thrilled to be a part of this dynamic department and hope to contribute to Genentech's success in the small molecule arena.

I was born in Iran and moved to the United States when I was 7 years old. Our summer vacation to Logan, Utah in 1978 resulted in a permanent move to the United States. We moved to California in the early 80's and I was lucky enough to take advantage of the University of California system from undergraduate through my Ph.D.

• My Focus

  My group is responsible for developing and validating enzyme and cellular assays in order to support small molecule drug discovery projects.

  We collaborate closely with scientists from the Pathway Biology groups in order to develop robust assays which are predictive of target biology. We also work closely with other members in the Biochemical Pharmacology, Early Leads, Assay Automation and Technology, and Medicinal Chemistry groups to support projects from high-throughput screening, lead validation, and lead optimization. Our mission is to do high-quality science, maintain a strong project focus, and work collaboratively with other departments at Genentech in order to accelerate small molecule programs into the clinic.

  I also serve as the project team leader for one of the early stage research oncology programs. In this capacity, I lead a multi-disciplinary team of scientists across various departments and oversee an external collaboration in order to identify novel development candidates.

• Publications

  • Pyrimidoaminotropanes as Potent, Selective, and Efficacious Small Molecule Kinase Inhibitors of the Mammalian Target of Rapamycin (mTOR)

    Journal of Medicinal Chemistry, 2013, ISSN: 0022-2623

    Estrada, Anthony A; Shore, Daniel G; Blackwood, Elizabeth; Chen, Yung-Hsiang; Deshmukh, Gauri; Ding, Xiao; Dipasquale, Antonio G; Epler, Jennifer A; Friedman, Lori S; Koehler, Michael F T; Liu, Lichuan; Malek, Shiva; Nonomiya, Jim; Ortwine, Daniel F; Pei, Zhonghua; Sideris, Steve; St-Jean, Frederic; Trinh, Lan; Truong, Tom; Lyssikatos, Joseph P

     View on PubMed

  • Non-Covalent Wild-Type-Sparing Inhibitors of EGFR T790M

    Cancer Discovery, 2012, ISSN: 2159-8274

    Lee, Ho-June; Schaefer, Gabriele; Heffron, Timothy P; Shao, Lily; Ye, Xiaofen; Sideris, Steve; Malek, Shiva; Chan, Emily; Merchant, Mark; La, Hank; Ubhayakar, Savita; Yauch, Robert L; Pirazzoli, Valentina; Politi, Katerina; Settleman, Jeff

     View on PubMed

  • Potent, selective, and orally bioavailable inhibitors of the Mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity

    Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

    Koehler, Michael F T; Bergeron, Philippe; Blackwood, Elizabeth; Bowman, Krista K; Chen, Yung-Hsiang; Deshmukh, Gauri; Ding, Xiao; Epler, Jennifer; Lau, Kevin; Lee, Leslie; Liu, Lichuan; Ly, Cuong; Malek, Shiva; Nonomiya, Jim; Oeh, Jason; Ortwine, Daniel F; Sampath, Deepak; Sideris, Steve; Trinh, Lan; Truong, Tom; Wu, Jiansheng; Pei, Zhonghua; Lyssikatos, Joseph P

     View on PubMed

  • Discovery and biological profiling of potent and selective mTOR inhibitor GDC-0349

    ACS Medicinal Chemistry Letters, 2012, ISSN:

    Pei, Zhonghua; Blackwood, Elizabeth; Liu, Lichuan; Malek, Shiva; Belvin, Marcia; Koehler, Michael F. T.; Ortwine, Daniel F.; Chen, Huifen; Cohen, Frederick; Kenny, Jane R.; Bergeron, Philippe; Lau, Kevin; Ly, Cuong; Zhao, Xianrui; Estrada, Anthony A.; Truong, Tom; Epler, Jennifer A.; Nonomiya, Jim; Trinh, Lan; Sideris, Steve; Lesnick, John; Bao, Linda; Vijapurkar, Ulka; Mukadam, Sophie; Tay, Suzanne; Deshmukh, Gauri; Chen, Yung-Hsiang; Ding, Xiao; Friedman, Lori S.; Lyssikatos, Joseph P.

     View on PubMed

  • Small-Molecule Ligands Bind to a Distinct Pocket in Ras and Inhibit SOS-Mediated Nucleotide Exchange Activity

    Proceedings of the National Academy of Sciences, 2012, ISSN: 0027-8424

    Fang, Guowei; Wang, Weiru; Rudolph, Joachim; Jackson, Peter K.; Mellman, Ira; Starovasnik, Melissa A.; Giannetti, Anthony M.; Wu, Jiansheng; Bowman, Krista K.; Ludlam, Mary J. C.; Stokoe, David; Malek, Shiva; Pan, Borlan; Fauber, Benjamin P.; Skelton, Nicholas J.; Anderson, Daniel J.; Pitts, Keith; Oh, Angela; Garrenton, Lindsay S.; Maurer, Till

     View on PubMed

• Education
  • University of California, San Diego, Ph.D., Biochemistry – 2000
  • University of California, Irvine, M.S., Chemistry – 1995
  • University of California, Los Angeles, B.S., Biochemistry – 1993
• Awards & Honors
  • Pre-doctoral Fellowship – 1998-2000
  • Molecular Biophysics Training Grant – 1996-1998
  • Outstanding Teaching Assistant – 1996-1997
  • Graduate Research Traineeship – 1994-1995
  • Outstanding Research Award in Biochemistry – 1993
  • Outstanding Research Proposal, UCLA Association of Chemists and Biochemists – 1991