I joined Genentech in 2006 after seven years in the Boston biotech sector, four of which were spent in a productive collaboration with scientists here at Genentech. The decision to become an East Coast transplant was driven by my passion to take small molecule drugs from concept to patients, and to do so in an environment driven by science and the desire to have a dramatic impact on patient outcome.

As a transition point between the bench and the clinic, the translational oncology group is focused on providing data that determines the relative efficacy of new agents and correlates efficacy with target inhibition and drug exposures to help inform clinical strategy.

• My Focus

  Currently, my laboratory supports several projects within the oncology pipeline including those aimed at targeting hedgehog and IAP pathways, as well as a number of projects targeting key signaling nodes downstream of cell surface tyrosine kinases. In addition, we continue to focus on identifying ways to improve the translational aspects of our work by gaining a more detailed understanding of pharmacokinetic and pharmacodynamic relationships for each of these targets. Such knowledge will enable more refined dose predictions in our clinical trials and ultimately lead to better decision-making and provide the right drug, at the right exposure, to our patients.

  We have also turned our attention to the identification of potential mechanisms of resistance to our drugs so that we can proactively develop treatment strategies that will reduce the potential for resistance as well as to treat resistant tumors should they arise.

• Publications

  • The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α

    Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

    Heffron, Timothy P.; Salphati, Laurent; Alicke, Bruno; Cheong, Jonathan; Dotson, Jennafer; Edgar, Kyle; Goldsmith, Richard; Gould, Stephen E.; Lee, Leslie B.; Lesnick, John D.; Lewis, Cristina; Ndubaku, Chudi; Nonomiya, Jim; Olivero, Alan G.; Pang, Jodie; Plise, Emile G.; Sideris, Steve; Trapp, Sean; Wallin, Jeffrey; Wang, Lan; Zhang, Xiaolin

     View on PubMed

  • Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response

    Clinical Cancer Research, 2012, ISSN: 1078-0432

    Wong, Harvey; Choo, Edna F.; Alicke, Bruno; Ding, Xiao; La, Hank; McNamara, Erin; Theil, Frank-Peter; Tibbitts, Jay; Friedman, Lori S.; Hop, Cornelis E. C. A.; Gould, Stephen E.

     View on PubMed

  • Anti-tumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response.

    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, ISSN: 1078-0432

    Wong, Harvey; Choo, Edna F; Alicke, Bruno; Ding, Xiao; La, Hank; McNamara, Erin; Theil, Frank-Peter; Tibbitts, Jay; Friedman, Lori S; Hop, Cornelis Eca; Gould, Stephen E

  • Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties

    Journal of Medicinal Chemistry, 2012, ISSN: 0022-2623

    Mathieu, Simon; Gradl, Stefan N; Ren, Li; Wen, Zhaoyang; Aliagas, Ignacio; Gunzner-Toste, Janet; Lee, Wendy; Pulk, Rebecca; Zhao, Guiling; Alicke, Bruno; Boggs, Jason W; Buckmelter, Alex J; Choo, Edna F; Dinkel, Victoria; Gloor, Susan L; Gould, Stephen E; Hansen, Joshua D; Hastings, Gregg; Hatzivassiliou, Georgia; Laird, Ellen R; Moreno, David; Ran, Yingqing; Voegtli, Walter C; Wenglowsky, Steve; Grina, Jonas; Rudolph, Joachim;

     View on PubMed

  • Pharmacokinetic–Pharmacodynamic Analysis of Vismodegib in Preclinical Models of Mutational and Ligand-Dependent Hedgehog Pathway Activation

    Clinical cancer research : an official journal of the American Association for Cancer Research, {Clin-Cancer-Res}, 15 Jul 2011 (epub: 24 May 2011), vol. 17, no. 14, p. 4682-92, ISSN: 1078-0432.

    Wong, Harvey; Alicke, Bruno; West, Kristina A; Pacheco, Patricia; La, Hank; Januario, Tom; Yauch, Robert L; de Sauvage, Frederic J; Gould, Stephen E

     View on PubMed

• Education
  • University of California, San Francisco, Department of Orthopedic Surgery, Postdoctoral Fellow – 1998
  • University of Virginia, Department of Biology, Postdoctoral Fellow – 1996
  • University of Connecticut Health Center, Department of Developmental Biology, Ph.D. – 1993
  • University of Massachusetts, North Dartmouth, B.S. – 1986
• Awards & Honors
  • New Investigator Award, Orthopedic Research Association – 1998
  • American Cancer Society Postdoctoral Fellowship – 1995-1998
  • Neural Behavior and Development Training Grant Postdoctoral Fellowship – 1994-1995
  • Lepow Award for Outstanding Achievement, University of Connecticut Health Center – 1992
  • Pre-doctoral Fellowship, University of Connecticut Health Center – 1989-1991