How to Get Into the Brain

Ryan Watts and Mark Dennis explain how they found a new way to get medicines through the blood-brain barrier, and how Genentech supports groundbreaking science.

Learn more about Ryan Watts and Mark Dennis in our scientist profiles section.

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Journal of Experimental Medicine, January 2014

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
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Science Translational Medicine, May 2013

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier 
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Science Translational Medicine, May 2011
Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
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Science Translational Medicine, May 2011
A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo
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