Discovering and Overcoming Roadblocks in Crossing the Blood-Brain Barrier

Bispecific TfR/BACE1 antibodies have shown promise for boosting antibody uptake in brain. The blood-brain barrier (BBB) continues to hinder the development of therapies for neurological…

Understanding Lung Cancer

Get the facts and know your risk…

Systemic and Polyarticular Juvenile Arthritis

Learn the common symptoms, diagnosis, and treatment options for polyarticular juvenile idiopathic arthritis (PJIA) and systemic juvenile idiopathic arthritis (SJIA). PJIA and SJIA are types…

Calling All Citizen Scientists

We recently received an intriguing plea for help from one Ralph Swoyer, an artisinal cheese maker known for his local cheese, Ralph's Killer Muenster. Ralph reached out to us because of our…

What is HER2-Positive Metastatic Breast Cancer?

Learn about metastatic, or advanced, breast cancer, which may also be HER2-positive…

Understanding Antibody-Drug Conjugates

ADCs combine three components to provide a unique treatment option…

How to Get Into the Brain

Ryan Watts and Mark Dennis explain how they found a new way to get medicines through the blood-brain barrier, and how Genentech supports groundbreaking science…

Our Research Vision

Rigorous and groundbreaking science has always been at the core of what we do at Genentech. Our unique emphasis on strong basic research combined with an applied focus on translational…

Genentech, Inside and Out

Mark Helton, a US Air Force veteran, discusses life inside and outside Genentech, and how working here gives him a sense of purpose…

Alzheimer's Prevention Trial - About Genentech's Involvement

Genentech, the Banner Alzheimer's Institute, and the National Institutes of Health are collaborating on the first-ever prevention trial in cognitively healthy individuals who are likely to…

Alzheimer's Prevention Trial - A Unique Patient Population

Genentech, the Banner Alzheimer's Institute, and the National Institutes of Health are collaborating on the first-ever prevention trial in cognitively healthy individuals who are likely to…

Alzheimer's Prevention Trial - Science and Significance

Genentech, the Banner Alzheimer's Institute, and the National Institutes of Health are collaborating on the first-ever prevention trial in cognitively healthy individuals who are likely to…

Gene Expressions: Understanding Biomarkers

Genentech scientist Jeff Settleman explains biomarkers and their potential for identifying which patients may benefit from certain treatments…

Science is Personal: Science

Breakthrough science is what we do…

Gene Expressions: The RAS-RAF Pathway: New Cancer Research

Chris Bowden, VP of Product Development at Genentech provides a close-up look at the RAS-RAF pathway, an important and evolving area of cancer research…

Gene Expressions: The Hedgehog Signaling Pathway and Cancer

Frederic de Sauvage, VP of Molecular Biology, explains Genentech's role towards understanding the relationship between the Hedgehog signaling pathway and cancer…

Gene Expressions: The HER Pathway and Cancer

Genentech VP of Clinical Oncology Dietmar Berger discusses the role of the HER2 receptor in metastatic breast cancer…

Gene Expressions: The Met Signaling Pathway and Cancer

Genentech scientist Bob Yauch explains the role of the Met signaling pathway in cancer, and how investigational medicines are targeting the pathway…