We are seeking a Scientific Manager in the Oncology Biomarker Development group within Development Sciences focusing on Genentech's Cancer Immunotherapy pipeline. The successful candidate will be involved in cross-functional project teams, and will play a role in reviewing and assessing the relevance of available biomarker data from clinical studies and will develop and assess scientific questions. He/She must be able to work in a collaborative environment and have flexibility in order to focus on high priority goals of the department and program teams. A strong background in cancer immunotherapy, immunology, or oncology, evidenced by peer reviewed publications in top tier journals, is a must. Analytical and/or bioinformatics skills are desirable. The successful candidate is expected to effectively interact with cross functional teams, to help generate data supporting innovative publications focused on biomarker or disease research, and promote collaborative efforts to push biomarker science and/or technology forward.
Aid in the generation and analysis of large-scale, genomic, phenotypic, and molecular data from internal and external sources.
Play a role in designing, developing and implementing biomarker strategies for identification of patients more likely to benefit from cancer therapy.
Work with clinical scientists to implement and coordinate sample collection and analysis in clinical studies.
Write, review and coordinate biomarker plans in clinical trial protocols, regulatory documents and collaboration agreements.
Collaborate with internal and external scientific experts to build a disease strategy and identify novel biomarker strategies
Establish, track, and maintain relationships and data exchange with collaborators.
Can independently design and carry out experiments and/or data analyses that address significant drug developments questions. Designs subsequent experiments and/or data analysis plans upon interpretation of data.
Develop new methods to address project needs, adapting them to their own needs or developing new protocols themselves. Serves as a resource for state-of-the art practice in areas of expertise
Play a significant role in the accomplishment of departmental/team goals, that directly impact significant drug development decisions and milestones.
Outstanding record of accomplishment in his/her field as evidenced by co-authored or primary authored internal technical reports, patents, manuscripts or regulatory documents such as IBs, INDs/CTAs, NDAs/BLAs, and responses to regulatory questions.
Broad use and application of current theories and principles of Oncology and Immunotherapy, use of techniques of the relevant areas of science, drug and assay development.
Effective communicator of ideas, project goals and results. Organizes and independently presents work at department, company and/or and project team meetings Presentations are clear and effective.
Effective written communicator of ideas and results. Independently completes internal technical reports and may be a co-author or primary author and manuscripts. Writing requires little revision, and authors documents independently and of high quality. May independently contribute to regulatory submissions as appropriate. May edit and review internal reports written by others.
Actively participates, Demonstrates and fosters teamwork at the group, department, and team levels. Represents department in team meetings. Acts as a resource within the department in a recognized subject or technology.
Defines approaches and expectations to achieve pre-defined goals to team. Provides timely feedback. Anticipates resource needs.
Candidate must have:
PhD degree in a relevant scientific field (e.g. immunology, molecular biology, cancer genetics, cancer biology, molecular oncology).
Minimum of 3-7 years post-doctoral experience in basic or translational research either in an academic and/or industry
Familiarity with methodologies and platforms used for analyzing high-content NGS data. Contribute in the strategic development of personalized medicine in oncology.
Outstanding scientific and organizational skills are a must.
An interest in clinical development and oncology is required.
Excellent verbal and written communication, and presentation skills.
Independent and critical thinking and the ability to make data supported decisions.
Experience in clinical drug development and biomarkers is beneficial, including basic or advanced understanding of critical development functions, e.g. Clinical Pharmacology, Regulatory, Safety, Operations, Biostatistics, etc.
Similarly, knowledge and understanding of current methods being used to assess function of immune system in tumors in clinical setting is a plus.
Who We Are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry
for more than 40 years, using human genetic information to develop novel medicines for serious and
life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious
illnesses. Please take this opportunity to learn about Genentech where we believe that our employees
are our most important asset & are dedicated to remaining a great place to work.
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