Senior Scientist/Computational Toxicologist, Development Toxicology

South San Francisco
California, United States of America

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The Position

The Department of Safety Assessment is responsible for the nonclinical safety assessment of all drug candidates in the portfolio of Genentech from the discovery phase up to support of marketed products. Safety Assessment provides scientific leadership and plays an active cross-functional role in the drug development process. Within Safety Assessment, Development Toxicology provides toxicology support to the Development small molecule and biotherapeutics portfolio from clinical candidate selection up to post-marketing support. We are seeking a Senior Scientist/Computational Toxicologist to support the project teams in identifying and mitigating Safety concerns by developing and applying computational approaches. This role will involve working in a collaborative team environment as part of the comprehensive safety assessment of Genentech therapeutics by providing toxicology representation and expert guidance to discovery and development teams. This role will also involve cross-functional collaboration with computational experts in related disciplines such as computational chemistry and computational DMPK.


The successful candidate for the role has expertise in the field of toxicology, chemistry, biology, pharmacology or similar, as well as hands-on experience in some computational application such as cheminformatics, machine learning or computational biology.  The Senior Scientist/Computational Toxicologist will work in a collaborative team environment within Safety Assessment and will partner with Discovery Toxicology to develop strategies and incorporate computational tools to support the design of molecules with favorable properties to avoid potential safety liabilities. This may involve supporting activities such as integration of predictive in silico models for profiling of chemical libraries or compound design, supporting problem solving activities within the drug project teams by investigating structure activity relationships and understanding off-target safety issues. It will also include working collaboratively with the Investigative Toxicology group to leverage data and mechanistic understanding by applying computational analysis and methodologies. The candidate will balance the development, integration and promotion of computational approaches into the workflows of the discovery projects with the ad hoc nature of problem solving in project teams as needed, and will be required to have an adaptive and flexible working style.

Depending on the successful candidate’s background and interest, other responsibilities may also include involvement in the risk assessment of drug impurities in accordance with the ICH M7 guideline or supporting projects as a part time Discovery Toxicologist. 

Working in a collaborative team environment, the Senior Scientist/ Computational Toxicologist provides expert advice/ guidance to peers and senior leaders in Safety Assessment and to project and technical teams, and represents Safety Assessment at related internal review boards in support of program advancement. In addition, the successful candidate represents Genentech in the external scientific community and plays an active role in cross-industry initiatives or at scientific conferences/ professional societies. Experience with cross-functional teams and capability to build productive cross-functional internal and external collaborations are desired.


  • A PhD in toxicology, chemistry, pharmacology or related field as well as demonstrated experience in informatics along with significant scientific achievements and 3-5 years of experience in the pharmaceutical industry or other relevant organization.
  • Demonstrated experience in extracting, compiling and analyzing complex data sets for building QSAR/machine learning models is a requirement. It is preferred that the candidate also has additional technical skills in the field of computational chemistry or computational biology.
  • Expertise in database generation and scripting in R or other widely used programming languages like Python is desired.
  • Experience in areas such as ICH M7 assessments, investigation of in vitro - in vivo correlations, analysis of omics-type data would be considered a plus.
  • Board certification in toxicology is not required but would be considered an asset.
  • The successful candidate must also demonstrate strong decision-making, complex problem solving, critical data analysis and interpretation, excellent written and verbal communication skills; and the ability to build productive cross-functional collaborations both within and external to Genentech.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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