Postdoctoral Research Fellow - Bioinformatics - Genentech Research

South San Francisco
California, United States of America

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The Position

Recently, exciting developments at Genentech and elsewhere have demonstrated the potential of leveraging the human immune system for effective and durable control of cancer. Genentech seeks a talented and highly motivated scientist to pursue post-doctoral research projects — jointly in collaboration with Richard Bourgon, in our Bioinformatics & Computational Biology Department, and with Shannon Turley, in our Cancer Immunology Department — and to contribute to the identification and development of the next generation of immune-based cancer therapies.

Candidates should possess strong experience with both computational and experimental techniques for studying the genetics and molecular biology of cancer. Experience investigating the immune system’s response to cancer is preferred though not required.

Ideally, candidates will independently identify a specific direction of research, though in broad terms, we expect projects to focus on the generation and interpretation of high-throughput genomic and other molecular data that increase our understanding of, for example,

  • The degree and nature of immune infiltration in the tumor microenvironment (TME);
  • Mechanisms by which tumors avoid immune surveillance or inhibit effector activity;
  • The impact of mutation or gene expression dysregulation on tumor neo-antigen presentation; or
  • Local or circulating biomarkers which predict response to immunomodulatory drugs or therapies. It would be of particular interest for future clinical work to establish correlations between aspects of the TME and cytokine or other measurements made in the periphery, as this would enable high-frequency longitudinal monitoring of disease or response to therapy.

Emphasis is on basic research, though on topics with eventual relevance to the clinic and to Genentech’s drug and biomarker development initiatives.

Of note, Genentech’s extensive high-dimensional molecular characterization of samples from immunotherapy clinical trials provide an outstanding opportunity for integrating pre-clinical and clinical findings.

A successful candidate will work with interdisciplinary teams, carry out experimental data generation, analysis and integration across various domains, and apply best-in-class algorithms — or develop new algorithms — that directly address the motivating biological and/or clinical questions.

Research projects are expected to lead to first-author publications in high-quality journals.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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