Senior Scientific Researcher, Protein Engineering, Genentech Research

South San Francisco
California, United States of America


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The Position

The position: 

We have a unique opportunity for a talented molecular biologist/protein engineer to join the drug discovery efforts within the Department of Structural Biology at Genentech. The Senior Scientific Researcher will be responsible for engineering antibodies to enable protein structure determination of challenging targets by X-ray crystallography and cryo-electron microscopy (cryo-EM). He/She will support small molecule pipeline projects as well as basic research projects where antibody chaperones for crystallization or cryo-EM are critical tools for protein structure determination.

The Senior Scientific Researcher will be responsible for all aspects of antibody engineering and characterization, including construction of antibody phage display libraries, in vitro selection of conformation-specific antibodies by phage display, epitope binning and affinity measurement by surface plasmon resonance (SPR), sequence analysis, and small-scale antibody fragment purification. The Senior Scientific Researcher will be expected to collaborate closely with colleagues in both the Structural Biology department and across Research, effectively present their scientific findings to a broad audience, contribute to external publications, and be a productive member of multidisciplinary project teams.

Who you are:

This position requires a M.S. degree in molecular biology, biochemistry, or a related field with 8+ years of relevant working experience or a Ph.D. with 0-3 years of postdoctoral experience. The candidate must have exceptional molecular biology skills as evidenced by a strong publication record. Experience in antibody or protein engineering, directed evolution using display technologies (phage, yeast, mRNA, or ribosome display), and a working knowledge of structural biology are a plus. The successful candidate will be a highly motivated and detail-oriented researcher, driven to solve complex scientific problems. Outstanding oral and written communication skills, as well as the ability to work both independently at the bench and in a collaborative environment are required.

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Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.


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