South San Francisco
California, United States of America
The Purification Development Department at Genentech invites applications for a full-time postdoctoral research position focused on the computational mechanistic modeling of preparative protein chromatography. Mechanistic modeling is the in silico prediction of chromatographic separation of proteins based on first principles of mass transfer through porous media and thermodynamics of protein binding. Mechanistic modeling is a key capability being developed in Purification Development, with the potential to reshape future process development.
This position will focus on augmenting existing mechanistic modeling approaches to expand capabilities with novel resin functionalities, as well as improving the modeling of heterogenous impurity populations, through a primarily computational approach. Although no direct laboratory experience with chromatography is necessary, this work will require interaction with laboratory scientists -- a willingness to participate in laboratory experiments is helpful. This work may directly impact future regulatory filing strategy for commercial large-molecule products.
Successful candidates will be highly motivated to work independently in a collaborative environment, and establish productive working relationships with colleagues across the company. Candidates must have a Ph.D. in Applied Mathematics, Computer Science, Engineering, Biochemistry, or related discipline with a physical quantitative focus. Candidates will ideally have experience in mechanistic modeling as demonstrated by a first-author paper published or accepted in a peer-reviewed journal. Programming experiences (i.e. Python, Matlab) is highly desireable. Familiarity with protein chemistry and bioseparations (including column chromatography) would be helpful. The candidate must have strong analytical, collaborative, communication and organizational skills, and should be open to performing experiments in a laboratory setting.
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
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