Associate Scientist, OBD

South San Francisco
California, United States of America

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The Position

We seek a highly motivated and capable Associate Scientist to contribute to biomarker research efforts in support of Genentech’s drug development pipeline in hematologic malignancies, with a focus on cancer immunotherapy (CIT).  Specifically, this individual will design and execute laboratory experiments, and oversee laboratory work by external Contract Research Organizations (CROs), to generate data regarding disease biology, patient subsets, and the biologic effects of therapeutic agents.

The candidate should have hands-on experience with mammalian cell culture and the culture and processing of primary samples such as blood and bone marrow aspirate, and should be proficient in flow cytometry data collection and analysis. The ideal candidate will also be familiar with methodologies for DNA/RNA isolation and quantification, as well as phenotypic and functional characterization of immune cells (e.g. cytokine release assays, cell killing assays, ELIspot, multimer staining).  Expertise in human immunology, cancer immunotherapy, oncology, cancer cell signaling pathways, and translational research is highly desirable.

The successful candidate is expected to work seamlessly as part of a multifunctional team, have excellent oral and written communication skills, participate and contribute to team meetings, publish in high quality scientific, technical or medical journals, and present at internal and external meetings.

Scope of position:

The Associate Scientist will report to a Senior Scientist/Scientist in the Oncology Biomarker Development (OBD) department within the Development Sciences Division of Genentech Research and Early Development. The individual will be responsible for biomarker research efforts supporting one or more molecules and disease in the Hematology disease area.   Scope of biomarker activities will span predictive, pharmacodynamic, and prognostic biomarkers as well as surrogate response markers such as MRD (minimal residual disease). The Associate Scientist will be responsible for contributing to Genentech research into the immunobiology of heme malignancies, translating preclinical hypotheses into a clinical biomarker strategy, generating insights, performing hypothesis testing and target validation and discovery from clinical biomarker samples.

Job Responsibilities

  • Design, conduct, and analyze laboratory experiments in the areas of cancer immunobiology and hematology
  • Collaborate with scientists across different departments at Genentech to accomplish research goals
  • Participate in and contribute to team meetings, such as presenting experimental plans and results
  • Understand and incorporate learnings from external research through regular review of the scientific literature and attending scientific conferences; regular publication of scientific and methodological results is strongly encouraged
  • Oversee laboratory work by external Contract Research Organizations (CROs)
  • Become an internally-recognized thought leader in the immunobiology of heme malignancies and an internal expert resource in one or more key laboratory techniques.

Job Requirements

  • Ph.D. degree in life science.
  • 0-2 years of postdoctoral work, and/or work experience in the biotech/pharma industry
  • A flexible mindset, with strong interpersonal, communication, and problem solving skills.
  • Successful demonstration of initiative, teamwork, collaboration and technical expertise.
  • Independent and creative scientist, as evidenced by a strong publication record.
  • Ability to create and establish priorities, manage work plans, and meet timelines.
  • Ability to identify, evaluate, implement, and become proficient in novel laboratory techniques.
  • Demonstrated expertise with cell culture including primary cell culture, and the handling of rodent and human tissues such as blood and bone marrow samples
  • Hands-on experience with flow cytometry data generation and analysis
  • Experience with phenotypic and functional characterization of immune cells
  • Familiarity with standard RNA/DNA and protein analysis techniques


  • Familiarity with next-generation sequencing (NGS) methods and immunohistochemistry techniques
  • Experience with mouse models of leukemia or other hematologic malignancies.
  • Experience in hematology and/or immunotherapy
  • Familiarity with 3 dimensional cell culture
  • Ability to perform analysis of large datasets e.g RNAseq data.



Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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