Senior Scientist, Preclinical and Translational Pharmacokinetics and Pharmacodynamics (PTPK)

South San Francisco
California, United States of America

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The Position

The Preclinical and Translational PKPD (PTPK) Department at Genentech, Inc. is seeking a PhD level scientist who is driven to understand the pharmacokinetics (PK) and pharmacodynamics (PD) of novel drug candidates. The candidate will be responsible for investigating the pharmacokinetics, biodistribution, and PKPD relationships of novel therapeutics in preclinical models to identify optimal lead candidates for further development, and for translating preclinical PKPD information to patients to ensure appropriate dose/regimen decisions using state-of-the-art experimental and quantitative approaches. The candidate will be working in close partnerships across various functions including Research Biology, Bioanalytical Sciences, Safety Assessment, Biomarkers, Clinical Pharmacology, Clinical Sciences, Biostatistics, CMC, and Regulatory. The candidate will represent the department on cross- functional project teams as a PKPD representative and present PKPD results at cross- functional teams, department meetings, review committees, and conferences. This role will provide the opportunity to lead teams and potentially manage 1-2 direct reports.

Who You Are

We are looking for individuals who are inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture.

  • A Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Biomedical Engineering or related discipline.
  • Minimum of 7+ years of relevant PKPD experience (post-doctoral experience included) and demonstrated impact on drug development and/or the PKPD scientific landscape.

Preferred qualifications:

  • Strong knowledge and experience in either oncology, immunology, and/or tumor immunology are highly desired.
  • Strong knowledge and experience in PK and PK/PD of large molecule therapeutics (e.g., monoclonal antibodies, bispecifics, fusion proteins, antibody-drug conjugates, etc.) are highly desired. Working knowledge of PK/PD software (e.g., WinNonlin, NONMEM, ADAPT II, SimBiology, etc) and the ability to analyze and critically assess PK/PD data is essential.
  • The candidate should have experience working on cross-functional teams, demonstrate excellent communication skills, and have the ability to work independently and effectively.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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