Principal Scientist, Oncology Biomarker Development – Lung, Head and Neck Cancer

South San Francisco
California, United States of America

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The Position

We are seeking a dynamic thought leader in oncology translational sciences / medicine to join the Oncology Biomarker Development (OBD) group at Genentech. The Principal Scientist of predictive diagnostics will provide exceptional scientific and strategic leadership for therapeutic franchises and disease-based biomarker activities in Cancer Immunotherapy with a specific focus on lung and head and neck cancers. The position may include oversight of targeted drugs outside of the cancer immunotherapy space that are being developed primarily in lung or head and neck cancers.  Leading a team of lab-enabled scientists / Sr. scientists, the incumbent will be responsible for development and oversight of the Franchise biomarker strategies and ensuring successful execution of drug-diagnostic co-development in collaboration with the Companion Diagnostics Development group within OBD. The successful candidate may also serve as a Biomarker Subteam leader for one or more molecules within their Franchise area. This role requires an individual with outstanding communication and leadership skills, as well as the ability to build strong relationships with key stakeholders in product development and other relevant functions and navigate challenging situations. The individual must also be viewed as a strong scientific and strategic leader, one who can readily bridge between a cutting edge Research environment and a fast-paced clinical and product development organization. The successful candidate is expected to drive the publication of biomarker data in high quality scientific, technical or medical journals, to represent the department and programs at external meetings, to be a key representative to our investigators, and to promote collaborative efforts to forward the biomarker sciences field in general. This is an important leadership role with substantial visibility within Genentech / Roche organization.

As a Principal Scientist, you are expected to:

  • Lead and mentor a group of Scientists that lead biomarker programs and medical affairs managers in late stage development
  • Provide exceptional scientific leadership across multiple molecule teams, to your peers within OBD and to the organization in general with a particular focus on late stage development
  • Lead biomarker strategies at the lung franchise level, and lead one or more biomarker subteams
  • Represent biomarker related strategies and plans to late stage development review forums, decision committees and project teams.
  • Lead biomarker related regulatory strategies and interactions with health authorities around the globe including review of relevant regulatory documents
  • Lead and drive scientific and technical innovation collaboratively with other members of the Department (experience with NGS and blood-based technologies preferred)
  • Drive high quality publications in high impact scientific, technical or medical journals
  • Represent OBD externally through presentations at key National / International meetings, interactions with our key investigators
  • Participate and thrive in an interactive, team oriented culture


  • PhD, MD or PhD/MD degree in a relevant scientific field (e.g. Oncology, pathology, molecular biology, cell signaling, cancer genetics, cancer biology, bioinformatics)
  • Minimum of 5-10 years post-MD/PhD experience in an academic and/or industry setting
  • Ideally experienced in clinical drug development for lung cancer, including advanced understanding of critical development functions, e.g. Clinical Sciences, Biomarker Development, Translational Medicine, Clinical Pharmacology, Regulatory, Safety, Operations, Biostatistics, etc.
  • Ideally, at least 5-8 years of prior experience managing a group of research associates, scientists, managers, etc.
  • Significant experience leading subteams / teams; ability to drive to effective decisions and enable execution on programs
  • Consistent record of innovative contributions to translational sciences / development in lung cancer as evidenced by first / senior-authored publications in top-tier journals, patent authorship, filings
  • Recognized scientific leadership in lung cancer, National and / or International scientific reputation, evidenced by presentations at key national/international meetings
  • Strong passion to drive clinical innovation to improve outcomes for patients
  • Outstanding communication skills; ability to:
    • Lead, influence and motivate others
    • Navigate complex and difficult situations
    • Show strategic agility and ability to interface with multiple stakeholders
    • Distill complex issues and clearly articulate / present solutions


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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