South San Francisco
California, United States of America
We are seeking an independent and motivated researcher for a Postdoctoral Fellowship in Marie Evangelista’s laboratory in the Department of Discovery Oncology. The successful candidate will join a research team that combines cutting-edge gene engineering, imaging, biochemistry, functional genomics, and bioinformatics to uncover novel approaches to targeting oncogenic drivers. The successful candidate will also utilize quantitative approaches to understand how intratumor heterogeneity (ITH) impacts oncogenic dependency. In this regard, the candidate will have an opportunity to collaborate with a cross-functional team (including chemistry, biochemistry, structural biology, and translational oncology).
Selected publications from the Evangelista lab:
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. Cell. 2017 Feb 23;168(5):817-829
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State. Daemen A, Liu B, Song K, Kwong M, Gao M, Hong R, Nannini M, Peterson D, Liederer BM, de la Cruz C, Sangaraju D, Jaochico A, Zhao X, Sandoval W, Hunsaker T, Firestein R, Latham S, Sampath D, Evangelista M, Hatzivassiliou G. Cell Metab. 2018 Sep 4;28(3):383-399.
A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC. Dompe N, Klijn C, Watson SA, Leng K, Port J, Cuellar T, Watanabe C, Haley B, Neve R, Evangelista M, Stokoe D. PLoS One. 2018 Jun 18;13
For more information on the position, please email [email protected] or see https://www.gene.com/scientists/our-scientists/marie-evangelista
For more information about the postdoctoral program at Genentech, please visit: https://www.gene.com/careers/university-and-early-career/postdocs
A Ph.D in gene engineering, molecular biology, cell biology, biochemistry, or related field Detailed understanding of state-of-the-art molecular biology techniques Experience in quantifying cell heterogeneity such imaging, single cell analysis, FACs. Computational or bioinformatics experience would also be an asset. Preferences for experience working on a cross-functional team with an emphasis on translational research You have a demonstrated record of innovative scientific accomplishments as evidenced by at least one first-author paper published or accepted in a top tier journal. You enjoy working closely and collaboratively with bench scientists to solve complex biological problems
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