Postdoctoral Research Fellow - Discovery Oncology - Evangelista Lab

South San Francisco
California, United States of America


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The Position

We are seeking an independent and motivated researcher for a Postdoctoral Fellowship in Marie Evangelista’s laboratory in the Department of Discovery Oncology.  The successful candidate will join a research team that combines cutting-edge gene engineering, imaging, biochemistry, functional genomics, and bioinformatics to uncover novel approaches to targeting oncogenic drivers.  The successful candidate will also utilize quantitative approaches to understand how intratumor heterogeneity (ITH) impacts oncogenic dependency.  In this regard, the candidate will have an opportunity to collaborate with a cross-functional team (including chemistry, biochemistry, structural biology, and translational oncology). 

Selected publications from the Evangelista lab:

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.

Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K.  Cell. 2017 Feb 23;168(5):817-829

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State. Daemen A, Liu B, Song K, Kwong M, Gao M, Hong R, Nannini M, Peterson D, Liederer BM, de la Cruz C, Sangaraju D, Jaochico A, Zhao X, Sandoval W, Hunsaker T, Firestein R, Latham S, Sampath D, Evangelista M, Hatzivassiliou G.  Cell Metab. 2018 Sep 4;28(3):383-399.

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC. Dompe N, Klijn C, Watson SA, Leng K, Port J, Cuellar T, Watanabe C, Haley B, Neve R, Evangelista M, Stokoe D. PLoS One. 2018 Jun 18;13

For more information on the position, please email [email protected] or see https://www.gene.com/scientists/our-scientists/marie-evangelista

For more information about the postdoctoral program at Genentech, please visit: https://www.gene.com/careers/university-and-early-career/postdocs

Requirements:

A Ph.D in gene engineering, molecular biology, cell biology, biochemistry, or related field Detailed understanding of state-of-the-art molecular biology techniques Experience in quantifying cell heterogeneity such imaging, single cell analysis, FACs.  Computational or bioinformatics experience would also be an asset. Preferences for experience working on a cross-functional team with an emphasis on translational research You have a demonstrated record of innovative scientific accomplishments as evidenced by at least one first-author paper published or accepted in a top tier journal. You enjoy working closely and collaboratively with bench scientists to solve complex biological problems

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Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.


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