Senior Scientific Researcher, Biotransformation/drug metabolism

South San Francisco
California, United States of America

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The Position

The DMPK biotransformation group at Genentech is seeking a highly motivated individual to support development drug metabolism. Primary responsibilities include:

  • Hands-on LC/MS experience and proven abilities in determining the biotransformation pathways of drugs by drug metabolizing enzymes.
  • Profiling and identifying drug metabolites in in vitro and in vivo biological matrices using HPLC with radiometric detection and LC-MS/MS
  • Designing, executing and reporting biotransformation studies to support drug development and regulatory filings.


The level of the position is Senior Scientific Researcher (SSR).  Qualified candidates will meet the following requirements:

  • BS/MS degree in chemistry, biochemistry, pharmaceutical sciences or other relevant discipline
  • Hands-on experience with LC-MS and/or drug metabolism; 5+ years of experience in both LC-MS and drug metabolism with expertise in sample preparation and analysis, including metabolite structure elucidation by MS/MS.  Experience using radiolabels, conducting regulatory filing studies, and writing scientific reports preferred
  • Capable of working independently.  Good writing and verbal communication skills.

The Drug Metabolism and Pharmacokinetics (DMPK) group at Genentech is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state-of-the-art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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