Scientific Researcher / Senior Scientific Researcher, Drug Metabolism and Pharmacokinetics

South San Francisco
California, United States of America


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The Position

The Position / Responsibilities

We are seeking a highly motivated individual for a Scientific Researcher/Senior Scientific Researcher position in Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech. In the Drug Permeability/Transport lab researchers investigate the cellular permeability of novel small molecules, in particular peptides, and the roles of membrane transporters in the disposition of these drug candidates.

Key responsibilities for this position include hands-on experimentation using cell biology and biochemical techniques to characterize the interactions of peptides (<3000 Da) with cell membranes and drug transporters, thereby elucidating the mechanisms affecting in vivo and cellular permeability/transport and providing project teams with relevant information for the optimization and identification of lead compounds. These data will also be used to explain or enhance the cellular pharmacological response. The qualified candidate must be able to work in a team environment, collaborate with multidisciplinary researchers on various aspects of projects, and meet timelines efficiently and productively.

Requirements

Qualified candidates will possess the following skills and experience.

  • Bachelor’s degree in biological sciences, bioengineering, pharmaceutical sciences, or related discipline; candidates with a Master’s degree are encouraged to apply. Academic or industrial laboratory experience with ADME characterization of peptides (< 5 years) is desirable.

  • Technical background in membrane biology, biochemical and cell-based assays and peptide analysis (LC/MS) are highly desirable.

  • Understanding of peptide chemistry, stability and ADME are essential.

  • Tissue culture proficiency is required. Primary cell culture proficiency is preferred.

  • Proven ability to independently design, execute, and interpret experiments.

  • Flexibility to manage multiple projects simultaneously and advance research independently as well as being part of highly collaborative team is essential.

  • Scientific curiosity and strong work ethic, excellent critical thinking and verbal/written communication skills.

Drug Metabolism and Pharmacokinetics (DMPK)
The DMPK department is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

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Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.


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