Senior Scientific Researcher, Discovery Oncology

South San Francisco
California, United States of America

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The Position

The Department of Discovery Oncology at Genentech is seeking a highly talented, creative and motivated senior scientific researcher (SSR) to identify, validate, and mechanistically characterize novel oncology targets with the goal of developing life changing therapies. The focus of our lab is to identify novel cancer vulnerabilities, with specific emphasis in colorectal cancer, by leveraging innovative in vivo, in vitro and ex vivo model systems together with a broad range of functional technologies, i.e CRISPR, RNAi or small molecule approaches. To this end, the successful candidate will use a variety of genetic, biochemical, and cell biological techniques for target identification and pursuit of the underlying mechanistic link to disease. Candidates with a deep understanding of the mechanistic process that drive cancer progression and/or with extensive experience using genetic techniques (such as shRNA and CRISPR approaches) to study pathways involved in tumor cell growth are encouraged to apply. This is an ideal position for someone who enjoys the translational aspects of converting basic biology discoveries in cancer development into drug discovery programs and who thrives in a team environment.

Who You Are:

  • Qualified candidates will hold a doctoral degree in Cell Biology, Molecular Biology, Developmental Biology, Biochemistry, or a related field and have a successful track record as illustrated by a strong publication record, authorship on patents, or other tangible success metrics.
  • Proficiency in a broad range of biochemical, molecular, and cell biological techniques.
  • Key desired technical skills include cell line engineering using both lentiviral and CRISPR-based approaches, functional genomic screening techniques (both RNAi and CRISPR), cell proliferation assays (in particular 3D formats), cell biological assays including immunofluorescence and high content imaging, and biochemical techniques including western blotting, co-immunoprecipitation, and in vitro assays using purified components.
  • Excellent organizational, problem-solving, and verbal/written communication skills.
  • Flexibility in adapting to new techniques in accordance with evolving research program needs.
  • Ability and desire to work both independently and collaboratively in a dynamic research environment.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.

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