Lead PHC 2.0 Office of Innovation

South San Francisco
California, United States of America


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The Position

Genentech/Roche Pharmaceuticals is focused on translating excellence in science into effective medicines for patients. It combines cutting-edge research at Roche, Genentech in the US, and over 150 partners worldwide with global scale and reach in clinical development, manufacturing and commercial operations.

Focusing on immunology, ophthalmology, infectious diseases, oncology, and neuroscience, we firmly believe in the tremendous potential to translate science into therapies which reduce human suffering and help people live longer and healthier lives. Roche is looking for novel and innovative pathways for expanding drug development opportunities across the portfolio, with an aim to address unmet patient need. With our innovative products and impressive pipeline, we can offer a depth and breadth of opportunities for forward thinking, entrepreneurial and innovative individuals.

The Role

The Lead PHC 2.0, Office of I2O Innovation in Product Development, I2O will identify and lead innovative strategies to create personalized healthcare (PHC) 2.0 for I2O.

As a strategic thinker, with experience in drug discovery or clinical drug development, and strong scientific and communication credentials, you will lead activities to develop and implement the strategy for PHC 2.0 in I2O, by building the vision and establishing collaborations within Roche and with relevant external groups, including academic centers, health authorities, businesses, government institutions and other partners. As the PHC 2.0 lead for I2O within Roche, you will mobilize the organization behind your vision and strategy, including cross-functional and cross-organizational leadership to enable the next steps for PHC 2.0 in I2O. PHC 2.0 in I2O will allow Roche to realize the potential of novel and/or big data sources; through the establishment of analytical methods to assist in the identification and evaluation of new imaging and/or genetic biomarkers and therapies to treat high unmet need disease within the I2O space.

As a core member of the Office of I2O Innovation team you will take accountability for leading cross-functional engagement to achieve the following ambitious goals for PHC 2.0, specifically:

  • Establish and build upon cross-functional and cross-organizational networks, to identify opportunities to build coalitions to move the vision forward.
  • Utilize your depth of experience and scientific insight, to identify creative and successful paths to achieve this vision, including a discerning approach about when to partner with others across the organization vs. identify and engage expertise that may be needed from external sources.
  • Lead cross-organizational efforts and/or external expert collaborations utilizing an approach of working through others to bring out the talents of others achieve ambitious goals.
  • Work closely with internal stakeholders (including the joint PHC center of excellence, research & early development, biometrics, RWD and strategic innovation) and external stakeholders in leveraging accessible and comprehensive integrated databases
  • (e.g. genomic, biomarker, clinical and imaging data)
  • Partner with analytics experts to implement novel accessible analytical methods, e.g. machine learning, for large-scale data mining, with the ultimate goal of identifying new imaging and/or genetic biomarkers and new disease targets to advance product development
  • Evaluate the potential for novel sources of data to contribute to evidence generation throughout research and development, with potential applications for internal decision- making as well as generating high quality scientific evidence ?
  • Bring a global mindset to all projects with energy and enthusiasm to see the project moves forward.

Additional Responsibilities

  • Critical evaluation of potential strategic innovation proposals including molecular based strategies for future drug development, with a strong emphasis on clinical and scientific aspects.
  • Contribute to the identification and delivery of the best collaborative opportunities with the various Roche functions (including the Roche PHC 2.0 Center of Excellence) as well as external opportunities with academic groups, non-profit research organizations, biotech/pharma and technology companies.
  • Develop and maintain a strong collaboration structure custom-made to the particular collaboration (e.g., Lifecycle Teams)
  • Best represent Roche’s scientific excellence and high ethical standards when interacting with potential outside partners
  • Serve as a role model within Roche in developing a vibrant, entrepreneurial, environment supporting courageous leadership, innovation and collaboration. Promote a culture of scientific innovation and continuous improvement.
  • May manage teams in the delivery of program or collaboration objectives.

Who You Are

Advanced degree in a scientific discipline, PhD preferred, plus 7-10 years of relevant work experience. Will consider Master’s degree plus 12-15 years relevant work experience.

  • Good understanding of quantitative methods (e.g. biostatistics, bioinformatics, computational biology, etc.)
  • A proven leader with extensive experience in drug discovery, clinical/drug development in the biotechnology/pharmaceutical industry/academia and excellent understanding of drug development regulations.
  • Demonstrated results-focus and ability to deliver projects through lateral influence, relationship management, negotiation and facilitation
  • Demonstrated critical thinking and communication skills, to help identify the best innovative options to bring forward into pilot and experimentation as well as conduct thoughtful assessment of the learnings from the pilots.
  • Ability to integrate/translate abstract concepts into tangible, results oriented plans to allow for early application and learning as well as rapid iteration to build upon the experience.
  • Ability to deal successfully with ambiguity and persevere through multiple experiments with a focus on learnings as well as outcomes.
  • Strong peer networks within Roche, the pharmaceutical industry and/or academia is a plus.
  • Ability to identify and secure needed expertise to drive a project forward in a scientifically robust manner.
  • Highly organized, with the ability to work to tight timelines when needed and high level of budget accountability.
  • Excellent organizational and communication (both written and verbal) skills. Management and cross-functional leadership experience strongly preferred. People focus with openness to providing mentorship to others, including potential rotation candidates and fellows.
  • Willingness and ability to travel up to 15%, including international travel.

Additional attributes sought

  • Clinical development experience and judgment.
  • Drug Discovery experience in I2O related therapeutic areas, including knowledge of microbiome.
  • At the forefront of a changing and competitive environment Creative and innovative mindset.
  • Lives Roche values of courage, passion, integrity. Commitment to I2O and Roche strategy.
  • Ability to partner/work in a matrixed organization with cross-functional partners. Has worked at a premier company or academic institution with primary focus in a therapeutic area in I2O.

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Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

At Genentech, we share salary ranges with applicants during the recruiting process, if requested. Third party salary estimates may not be accurate or up-to-date.


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