Scientific Researcher/Senior Scientific Researcher, Large Molecule Biochemical and Cellular Pharmacology

South San Francisco
California, United States of America

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The Position

We have an opening for a talented Scientific Researcher/Senior Scientific Researcher to join our Biochemical and Cellular Pharmacology Department within Genentech’s Research and Early Development (gRED) organization.


The successful candidate will be responsible for supporting biochemical and cellular characterization of protein therapeutics for various therapeutic areas, including oncology, cancer immunology, inflammation and neuroscience. More specifically, the individual will develop, validate and execute biochemical and cell-based assays to characterize and screen biologic therapeutics in vitro and ex vivo, to support lead-finding and optimization efforts, as well as mechanistic characterization of candidates.  


Responsibilities include developing and implementing pharmacodynamic assays and quantitating biomarkers. In addition, the candidate will function as part of a multi-disciplinary project team that will coordinate with Antibody Engineering, Protein Chemistry, Therapeutic Area and Translational Research groups to advance lead molecules of the projects. The candidate will have the opportunity to present their work to project teams and senior management, and is expected to contribute to publications and present at scientific conferences.


Who You Are

  • B.S. degree (M.S. degree preferred) in Immunology, Biochemistry, Cell Biology, or a related field with 3 to 6+ years of relevant immunology/immuno-oncology and/or cell biology experience in academia, biotechnology and/or pharmaceutical industry
  • Practical experience in the design, development, validation and execution of biochemical and cell-based assays to characterize protein therapeutics
  • Experience with flow cytometry, cell-based functional assays, ELISA assays, and culture of mammalian cell lines and primary cells from various species
  • Ability to work independently to design, execute, and interpret experiments, and also collaborate with project teams
  • Record of publications that demonstrates expertise
  • Excellent teamwork, communication, time management, and organizational skills


Additional desirable skills

  • A strong foundation in immunology or cell biology and hands-on expertise in immune cell and/or other primary cell based assays to interrogate the function and bioactivity of antibody and protein therapeutics
  • Experience with primary immune other primary cell isolation, culture and differentiation
  • Experience with microscopy and/or high content image analysis
  • Experience with Luminex assays
  • Familiarity with automated or semi-automated instrumentation
  • Familiarity with the multi-disciplinary activities of antibody lead profiling


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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