Postdoctoral Research Fellow - Chan Lab

South San Francisco
California, United States of America

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The Position

Our laboratory focuses on understanding how alterations in immune cell function contribute to immunity and autoimmunity as well as how they may impinge on efficacy of targeted therapeutics. Areas of focus at present include: (1) Regulation by protein tyrosine kinases and phosphatases in immune and hematopoietic cell function, (2) Dysregulation of lymphocyte signaling in autoimmune disorders and cancer immunologic responses, (3) Regulation of lymphocyte function by the cytoskeleton. These studies provide important insights of how immunity is established and maintained as well as how dysregulation of these signaling nodes may contribute to disease and therapeutic responses.

Qualifications: Candidate should have a PhD in Immunology or Cell Biology, technical experience with methodologies in molecular biology, immunology and cell biology, ability to think innovatively and rigorously, and a strong publication record.

Recent Publications:

1.   Yu, J, et al., Surface receptor Toso controls B cell-mediated regulation of T cell immunity. Journal of Clinical Investigation 128:1820-1836, 2018. PMID:26774822

2.   Yang CW, et al, DENND1B regulates T cell receptor signaling in TH2 cells and allergic diseases. Cell 164:141-155, 2016. PMID: 26774822

3.   Holmes, DA et al, Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-alpha receptor signaling. Journal of Experimental Medicine 212: 1081-1093, 2015. PMID: 26077719

4.   Holmes, DA et al, Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. EMBO J 34: 218-235, 2015. PMID: 25398911

5.   O’Shea JJ, Kanno Y, Chan, AC. In search of magic bullets: the golden age of immunotherapeutics. Cell 157:227-240, 2014. PMID 24679538

Interested applicants should contact:

Andrew Chan, MD PhD


One DNA Way, MS 34

South San Francisco, CA 94080

Email: [email protected]

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

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