South San Francisco
California, United States of America
Our laboratory focuses on understanding how alterations in immune cell function contribute to immunity and autoimmunity as well as how they may impinge on efficacy of targeted therapeutics. Areas of focus at present include: (1) Regulation by protein tyrosine kinases and phosphatases in immune and hematopoietic cell function, (2) Dysregulation of lymphocyte signaling in autoimmune disorders and cancer immunologic responses, (3) Regulation of lymphocyte function by the cytoskeleton. These studies provide important insights of how immunity is established and maintained as well as how dysregulation of these signaling nodes may contribute to disease and therapeutic responses.
Qualifications: Candidate should have a PhD in Immunology or Cell Biology, technical experience with methodologies in molecular biology, immunology and cell biology, ability to think innovatively and rigorously, and a strong publication record.
1. Yu, J, et al., Surface receptor Toso controls B cell-mediated regulation of T cell immunity. Journal of Clinical Investigation 128:1820-1836, 2018. PMID:26774822
2. Yang CW, et al, DENND1B regulates T cell receptor signaling in TH2 cells and allergic diseases. Cell 164:141-155, 2016. PMID: 26774822
3. Holmes, DA et al, Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-alpha receptor signaling. Journal of Experimental Medicine 212: 1081-1093, 2015. PMID: 26077719
4. Holmes, DA et al, Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. EMBO J 34: 218-235, 2015. PMID: 25398911
5. O’Shea JJ, Kanno Y, Chan, AC. In search of magic bullets: the golden age of immunotherapeutics. Cell 157:227-240, 2014. PMID 24679538
Interested applicants should contact:
Andrew Chan, MD PhD
One DNA Way, MS 34
South San Francisco, CA 94080
Email: [email protected]
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