Scientist / Senior Scientist, Preclinical Translational (PKPD)

South San Francisco
California, United States of America

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The Position

The Preclinical Translational PKPD Department at Genentech, Inc. is seeking a Quantitative Systems Pharmacology Modeling & Simulation Scientist who is driven to enhance drug development through mechanistic modeling of biological systems. The Translational and Systems Pharmacology Group at Genentech was initiated in 2012 to lead both (1) preclinical & translational PKPD modeling of biologic therapeutics, and (2) systems modeling to support all stages of research and development across molecule types/formats.  Our group is comprised of scientists with PhDs in engineering and pharmaceutical scientists with expertise across mechanistic modeling and simulation, computational algorithm and tool development, and translating complex biology into mathematical models.  We work closely with collaborators across all disciplines in therapeutic areas such as oncology and cancer immunotherapy, immune and inflammatory disorders, ocular disease, neurological disorders, and more.  Communication and collaboration skills are thus critical skills.  The group has a significant external presence, with a growing list of publications in highly regarded journals in the field, numerous oral presentations, academic seminars, and workshop leadership.  Our members are leaders of various interest groups, conference programming committees, and working groups in the field of pharmaceutical modeling and simulation.  In addition to our application of systems modeling approaches in support of drug development, we are also committed to the development of new technical approaches, algorithms, and tools to advance the field.


 The Scientist/Senior Scientist will be responsible for developing and applying models of complex systems such as tissue and cell dynamics and intracellular signaling in various therapeutic areas including immune & inflammatory disease, oncology, and other disease areas. The successful candidate will have responsibilities developing QSP models in the context of specific molecule or therapeutic area needs, conducting in silico research to inform project team goals such as target/compound evaluation, biomarker and diagnostic investigation, human protocol determination, and combination therapy identification. The candidate will also have responsibilities using PKPD modeling and simulation to support large-molecule preclinical and translational efforts, with continued support as needed through approval. Maintaining close and effective partnerships with other preclinical and clinical PK/PD and biomarker scientists, safety scientists, research scientists, clinicians and project teams will be essential. An additional component will be the presentation of results at cross-functional teams, department meetings, review committees, and conferences. Qualified individual will also be responsible for overseeing the strategy and implementation of systems modeling efforts by other scientists across projects.


Ph.D in chemical, biomedical, or other relevant engineering fields, pharmaceutical sciences, or a related discipline. Typical experience for Scientists would be 3-6 years and Senior Scientist would be 7+ years in addition to a PhD. Candidates will have will have a proven track record and publications applying systems modeling and simulation approaches to biological systems and/or drug development either in industry or academia. Proficiency with systems modeling approaches such as differential equation, logic, stochastic, agent-based, or other advanced mechanistic modeling approaches is essential, as is experience with relevant software or programming languages (e.g., Simbiology, MATLAB, R, or C). Experience with modeling and simulation of large molecule PKPD is valuable but not required, as is familiarity with the biology of one or more disease areas. The candidate must have excellent communication skills and the ability to work independently and effectively on interdepartmental project teams to plan, organize, assess and perform model-based analyses. Leadership skills are highly desirable.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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