South San Francisco
California, United States of America
The mission of Translational Oncology is to discover new targets and identify and characterize first- and best-in-class clinical candidates. We help guide clinical development of these drugs though a deep understanding of their unique mechanisms of action, define patient populations that are most likely to respond and biomarkers predictive of this response. The In Vivo Pharmacology team provide xenograft, PDX, and syngeneic in vivo model systems to validate drug targets and identify drug candidates for advancement into clinical trials. We define pharmacodynamic-pharmacokinetic-efficacy relationships and use this information to inform drug exposure targets in the clinic.
The successful candidate can expect to spend approximately 75% of their time supporting in vivo studies for primary investigators with administration of test compounds via PO, IP, SC, IV routes in a sterile lab environment, sample collections (RO, various tissues), some animal husbandry tasks, and assisting with other related requests. The remaining 25% of the time will be focus on general laboratory managerial duties such as stocking, assistance with lab equipment calibrations, maintaining lab cleanliness, and appropriately disposing of biohazardous and chemical waste. These percentages may fluctuate depending on business needs.
Additional responsibilities for this position include health checks , assisting with transplants or surgeries, performing procedures requiring anesthesia, performing pre-lab checks prior to lab inspections, preparing sterile packs, assisting to ensure lab equipment are calibrated and working with biohazardous and chemical materials.
This position will require the candidate to be on a quarterly rotational work schedule of:
In addition, the candidate must have flexibility with regard to start/end time, as shifts outside of regular business hours may be required due to business needs.
Note: The workday will not exceed 8 hours, regardless of start/end time (unless overtime or comp time is discussed in advance and with managers approval). Candidate must also be able/available to work holidays and provide work coverage to their team mates, as needed. Shift assignments are subject to change depending upon business needs.
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.
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