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Scientist - Oncology, Translational Science, Biomarker Development

South San Francisco
California, United States of America

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The Position

We are seeking a highly motivated Scientist/Senior Scientist to support translational science and biomarker discovery efforts for Genentech's pipeline in lung and head and neck cancers within the Oncology Biomarker Development (OBD) group. Substantial expertise in oncology, biomarker discovery, companion diagnostics, regulatory filings, and translational research is highly desirable. The individual will serve as a study biomarker leader and will be responsible for designing and implementing biomarker strategy for studies within Genentechs’s immunotherapy portfolio. In addition, the incumbent will ensure successful execution of diagnostic strategies in collaboration with the Companion Diagnostic Development group and will support regulatory filings for associated pivotal studies. This role requires an individual with outstanding communication and leadership skills. The ideal candidate will be familiar with cutting edge biomarker discovery techniques, including NGS and multi-plex IHC technologies, assess and implement novel biomarker-driven surrogate endpoints, and present biomarker focused clinical data to study teams and the OBD group. The successful candidate is expected to drive the publication of biomarker data in high quality scientific, technical or medical journals, to represent the department and programs at external meetings, to be a key representative to our investigators, and to promote collaborative efforts to forward the biomarker sciences field in general. 

Primary responsibilities: 

  • Provide exceptional scientific leadership to molecule teams, to your peers within OBD and to the organization in general with a particular focus on late stage development 

  • Represent biomarker related strategies and plans to late stage development review forums, decision committees and project teams. 

  • Drive biomarker related regulatory strategies and interactions with health authorities around the globe including review of relevant regulatory documents

  • Harness existing study data sets to inform reverse translational research

  • Represent OBD externally through presentations at key scientific meetings and interactions with investigators 

  • Drive scientific and technical innovation collaboratively with other members of the department.  Participate and thrive in an interactive, team-oriented culture 


  • PhD, MD or PhD/MD degree in a relevant scientific field (e.g. cancer biology, molecular biology, immunology).  Post-doctoral training and previous industry experience preferred. 

  • Experience in clinical drug development for lung cancer, including advanced understanding of critical development functions, e.g. Clinical Sciences, Biomarker Development, Translational Medicine, Clinical Pharmacology, Regulatory, Safety, Operations, Biostatistics, etc

  • Minimum of 3-5 years postdoctoral basic or translational research experience in either academic and/or in an industry setting. 

  • Outstanding presentation and communication skills

  • Successful demonstration of initiative, teamwork, collaboration and technical expertise as an independent and creative scientist. 

  • Demonstrated record of scientific leadership as evidenced by first or senior authored publications in impactful journals 

  • Expertise in human immunology, cancer immunotherapy, oncology, cancer cell signaling pathways, and translational research is highly desirable.

  •  Roche is an equal opportunity employer. 





Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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