Senior Manufacturing Technician - Bioprocess

South San Francisco
California, United States of America


Return to Search Results

The Position

This position is responsible for producing innovative biotherapeutic medicine by interfacing with highly automated production systems and controls in cGMP manufacturing environment, and maintaining areas in high state of inspection preparedness. Operates production equipment for cell culture or purification that may include culture growth, process monitoring, sampling, harvesting, purification, formulation, freeze thaw and transfer. Performs media/buffer solution preparation operations. Maintains records and clean room environment to comply with regulatory requirements utilizing current Good Manufacturing Practices (cGMP) and Standard Operating Procedures (SOP).

Hiring for multiple positions:

  • 1 position for Days 1: Sunday - Tuesday, alternating Wednesday from 0700-2000
  • 1 position for Nights 2: Wednesday - Friday, alternating Saturday from 1900-0800

Responsible for being proficient in two or more functional areas and applies expert knowledge of mechanical, scientific principles, processes and biopharmaceutical processing equipment.

Responsibilities

Technician

  • Operate systems that clean and sterilize tanks and filtration systems. 
  • Prepare solutions for the production process.
  • Review documentation and check all calculations (e.g. tickets, labels, equipment reading).
  • Troubleshoot equipment and process problems.
  • Comply with safety requirements, cGMP, SOP and manufacturing documentation.
  • Use of automation to perform production operations.
  • Provide support to Manufacturing to meet production demands
  • Operate automated systems for equipment operation.
  • Assemble and prepare equipment for production
  • Exhibit detail oriented documentation skills
  • Communicate effectively and ability to work in a team environment.
  • Exhibit professional interpersonal skills.
  • Work with coworkers and supervisor to effectively troubleshoot equipment and process issues.
  • Follows established safety and environmental guidelines and procedures for all work performed.  Immediately reports safety and environmental incidents including injuries, illnesses, near misses, and safety suggestions.  Fosters a positive safety culture in which no one gets hurt.

Senior Technician

  • Provide coaching and training on best practices and compliance to SOPs.
  • Prepare solutions for the production process.
  • Participate in continuous operational improvement.
  • Provide reports to management summarizing goal unit attainment.
  • Work with coworkers and supervisor to effectively troubleshoot equipment and process issues.
  • Understands the theory, concepts, and regulations behind biopharmaceutical technology and processes. 
  • A strong knowledge of at least one manufacturing department with an understanding of process impact of other areas.
  • Anticipates potential problems and takes preventative action.
  • Requires judgment to know when it is necessary to consult with supervisor and/or support groups. 
  • Understands how own actions impact others and uses this information in decision-making.

Supplementary Responsibilities include:

  • Operate bioreactors, centrifuges, other harvest systems and protein purifications units.
  • Operate and clean fixed tank and filtration systems
  • Operate large scale column chromatography systems.
  • Operate small-scale cell culture areas and systems by operating cleaning, set up, and maintaining 20L bioreactors; inoculating and maintaining spinner seed cultures using aseptic techniques, maintaining cell banks; and performing general seed lab operations.
  • Perform CIP and SIP

Qualifications

  • Degree in Life Sciences or engineering and 3+ years of related experience, or Associate Degree and 5+ years of related experience, or High School and 7+ related years experience
  • Biotech certificate from approved program preferred
  • Excellent oral and written communication skills
  • Capable of writing detailed reports and summaries.
  • Must possess high level of automation and technical process knowledge as related to prep and process within area of responsibility.
  • Familiarity of computer-based systems
  • Background in fermentation or purification operations

Work Environment / Physical Demands / Safety Considerations

  • Schedule could include a non-rotating 3 or 4-day (12 hour shift including one weekend day), evening or night hours, or full off-shift hours.
  • Expected to be on feet for 8 to 10 hours a day.
  • Climb upwards of 6 flights of stairs a day to maneuver within the manufacturing facility.
  • Lift up to 40 lbs, Carry 40 lbs, Push/Pull force of 50lbs with full body, and Push/Pull force of 24lbs with arms only may be required.
  • Ability to bend and lift items from floor level, work with arm extended at chest height while making fine hand and finger manipulations, extend arms above shoulder level to manipulate equipment, and repetitive fine motor skills.
  • The clean room environment requires:
    • Gowning in the form of hospital scrubs, coveralls, gloves and steel toe boots must be worn
    • No make up or jewelry can be worn when working in the clean room environment
    • Work in clean room environment with large mechanical equipment, piping, and pumps connecting to tanks serviced by high-pressure steam, water and air together this creates a loud environment.
  • Work with hazardous materials and chemicals.

Please note that this position is not eligible for relocation. Only local candidates will be given consideration.

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.


Return to Search Results