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Postdoctoral Fellow - Antibody Engineering, Koerber and Hymowitz Labs

South San Francisco, California

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The Position

We have an exciting opportunity for a highly motivated Postdoctoral Fellow to join the Antibody Engineering department at Genentech.  The successful postdoctoral candidate will focus their research on understanding novel conformational and post-translationally modified states of proteins of therapeutic interest, with an emphasis on developing, characterizing, and applying conformation-specific antibodies.  While several targets of high interest have been identified, the opportunity to drive new projects and technology also exists.  The successful postdoctoral candidate will work closely with a highly collaborative group of scientists whose expertise includes antibody engineering, X-ray crystallography, and cryo-electron microscopy (cryo-EM).

This postdoctoral scientist will be responsible for the discovery of novel conformational antibodies and/or antibodies against novel post translational modifications and subsequent biophysical and structural characterization. The individual will also work with collaborators in Oncology and Immunology to apply these novel reagents to study cell signaling.  A proven track-record in protein engineering is highly desirable. Experience in structure determination (X-ray crystallography and/or cryo-EM) is a plus.

Required Qualifications: PhD in biochemistry, biophysics, bioengineering, and/or structural biology with strong experience in protein biochemistry.  Productive doctoral training is expected and should be reflected through a record of high-impact publications.

Additional Recommended Qualifications:

  • Strong background in molecular biology

  • Proficient in characterizing and engineering proteins or enzymes using analytical biochemical and biophysical methods is preferred

  • Experience with structure determination using X-ray crystallography and/or cryo-EM

  • Excellent communication, interpersonal and organizational skills

Relevant Papers:

Rouge L et al. Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab. Science Mar 13; 367(6483):1224-1230 (2020).

Liau N et al, Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3 induced dimerization. Nat. Struct. Mol Biol Feb 27(2):134-141 (2020).

Storek KM et al. Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD. Elife Jun 25; 8e46258 (2019).

Haling JR et al., Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling. Cancer Cell Sep 8;26(3):402-413 (2014).

Koerber JT et al. Nature-inspired design of motif-specific antibodies. Nat Biotech Oct 31(10):916-21 (2013).

More information about the Genentech Postdoctoral Program:

More information about the labs of JT Koerber and Sarah Hymowitz:



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