Scientist/Senior Scientist, Drug Metabolism and Pharmacokinetics

South San Francisco
California, United States of America


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The Position

The Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech is seeking a highly motivated leader who will be supporting small molecule projects in discovery and development.  

The DMPK group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state of the art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

The individual would lead the DMPK project strategy, design and execute non-clinical studies in a highly collaborative environment.  This position will require knowledge of ADME, with focus on PK and PK/PD modeling.

The individual will be involved in the following activities as part of their role:

  • Representation of DMPK at interdisciplinary project teams
  • Pharmacokinetic & pharmacodynamic data analysis and modeling
  • Author report/sections for regulatory filings, i.e., IND and NDA filings
  • Managing and mentoring scientists

Required Qualifications:  

  • A PhD degree in pharmacokinetics, drug metabolism or other relevant field   
  • Good understanding of ADME with proven scientific expertise in this field
  • Good communication, managerial and organizational skills and the ability to work in multifunctional teams are essential

Preferred Qualifications:  

  • 5-10 years of relevant pharmaceutical industry experience as a DMPK project leader / representative
  • Familiarity with various modeling software packages such as MatLab, ADAPT, SAAMII and NONMEM is highly desired

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Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.


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