Intern - Research and Early Development - Drug Metabolism Pharmacokinetics (Graduate Level)

South San Francisco
California, United States of America

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The Position

Start Date: Summer 2020

Work Hours: 40 hours per week

Location: South San Francisco Campus

Length of Assignment: 3 months

Department Overview: The mission of the Drug Metabolism and Pharmacokinetics (DMPK) group is to enable the discovery, selection, development, and commercialization of safe and effective medicines for significant unmet medical needs by elucidating the absorption, distribution, metabolism, elimination and pharmacokinetic properties of small molecule drug candidates. We accomplish this through application of state-of-the-art technologies and sciences of bioanalysis, drug metabolism and disposition, innovative thinking, effective collaboration and teamwork. We commit ourselves to high standards of ethics, integrity, scientific excellence, diversity, trust and respect for people.

Here are some examples of the projects we have for interns this summer…

Intern Project #1

Education Level: PhD Student (pursuing PhD, not completed)

Preferred Competencies: Microbiome, metabolism/biotransformation, and pharmacokinetics

Intern Responsibilities:

  • Design studies to understand how the microbiome may alter the disposition of drugs and affect bioavailability
  • In vitro incubations of drugs under anaerobic conditions
  • Investigating the biotransformation of drugs (using mass specs)

Intern Project #2

Education Level: Master of Science (1st or 2nd Year or recent grad) OR PhD Student (pursuing PhD, not completed)

Preferred Qualifications: Experimental microbiology (anaerobic bacteria culturing), metabolomics (LC-MS), drug/xenobiotics metabolism, large metabolomics/bacteria sequencing dataset analysis

Intern Responsibilities:

  • Build the human microbiome isolate library (optimize culture conditions)
  • Validate the microbiome library with probe compounds known prone to microbial-derived metabolism (e.g. sulfasalazine, methotrexate)
  • Apply the microbiome library to study discovery compounds with possible microbiome implications (highly variable PK in vivo, new modality like peptides with moieties vulnerable to hydrolases by gut microbiome).
  • Use LC-MS to identify drug molecules and metabolites, determine the metabolic rate and fate of drug molecules in biological samples

Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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