South San Francisco
California, United States of America
The OMNI-Biomarker Development department at Genentech provides translational science support to inform the clinical development of novel personalized therapeutics in disease areas of Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases (OMNI). Our biomarker strategies are designed to study the molecular pathways driving the disease and to establish the mechanism of action of our therapeutics. We focus on prognostic, predictive and pharmacodynamic biomarkers to enable our vision of “the right drug for the right patient at the right dose”.
We are seeking a talented and highly motivated Bioinformatics Scientist / Senior Scientist to lead our internal bioinformatics strategy. The candidate will initially focus on Immunological diseases such as Inflammatory Bowel Disease or COPD and translate complex molecular data into insights on disease heterogeneity and mechanism of action of our therapeutics. The position is expected to evolve to a broader strategic role in alignment with the expected growing needs of the portfolio. The candidate will work closely with the Bioinformatics and Computational Biology Department in Research.
The successful candidate will join our dynamic team and lead computational biology efforts that advance personalized healthcare in areas of immunological disorders, such as IBD or COPD. The candidate will support our disease biomarker strategies, leading data analysis efforts for internal studies and external collaborations relating to understanding clinical aspects of disease through genetics, transcriptomics, and other biomarker data across clinical data sets. Success in these responsibilities requires a thorough understanding of disease and drug target biology, creativity and attention to detail, and experience in integrating biomarkers into clinical trials. Candidates with experience in exome and genome sequencing, bulk or single-cell RNA sequencing, bioinformatics, or data algorithms including machine learning will be given preference. A successful candidate will work with interdisciplinary teams including discovery research, biomarker, clinical, biostatistics, and bioinformatics scientists, and will carry out data analysis and integration across various domains. Regular publication of scientific or methodological papers is an important component of this position. Success critically depends on an ability to effectively present complex techniques and results in a clear and concise manner to a diverse audience of scientists.
Who you are
You have a PhD in Bioinformatics, Biostatistics, Computational Biology or similar field, with at least 2 to 5 years of post-doctoral experience in basic or translational research in the field of Immunology.
You have a strong scientific publication record.
You enjoy using creative and novel informatic approaches and datasets to bring new insights to biological problems, and then working closely with biomarker scientists to develop those ideas experimentally.
You have experience working with high dimensional data (e.g. single cell sequence assays, genotype or WGS data, proteomics data, etc.).
You have demonstrated competence in languages such as R or Python for bioinformatics analyses.
You are intensely curious about the biology of disease and eager to contribute to scientific efforts focused on understanding the molecular mechanisms underlying disease etiology.
You are able to present complex results, both verbally and in writing, to computational and non-computational audiences.
You can work successfully as the bioinformatics lead in cross-functional teams that contribute to drug and biomarker development.
Senior Scientist level
All of the above, and:
You have demonstrated experience directing scientists (e.g., PhD students, post-docs, scientists or other researchers in an industry setting) who each work independently on a diverse set of research projects. You also have demonstrated ability to direct the scientific and professional development of such scientists.
You have sophisticated understanding of relevant concepts in Immunology and Computational Biology.
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.
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