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Senior Scientific Researcher, Oncology Biomarker Development

South San Francisco, California

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The Position

Primary role

We seek a highly motivated Senior Scientific Researcher to contribute to Genentech’s ground-breaking reverse translation efforts.  The candidate will join a new team of researchers on Genentech’s vibrant research campus in South San Francisco, with the goal of identifying and validating novel mechanisms of response and resistance in support of Genentech/Roche’s early and late-stage assets.

  • Cancer Immunotherapy (CIT): Qualified candidate will participate in the discovery and investigation of novel drug targets in the therapeutic area of tumor inflammation and immunology. Using state of the art techniques and technologies, he/she will be involved in the purification of immune cells for in-vitro cell culture, T cell functional assays including in vitro stimulation, multi-color flow cytometry, and investigation of new molecular pathways using cellular and molecular techniques to investigate receptor/ligand interactions for potential therapeutic utility.  Direct experience with animal models of immune response and/or anti-tumor immunity is preferred.


  • Responsible for translational research to enable the development of biomarkers and assays for use in the clinical development of our candidate medicines. 
  • Experimental strategies will include the application of state of the art molecular and genomic technologies to analyze clinical samples.
  • Specific responsibilities will include processing and analyzing clinical trial samples, data analysis, and presentation, and contributing to experimental design and planning.


  • Successful candidates will have a BS, MS degree, and at least 6 years of hands-on laboratory research experience.
  • You will have an intimate knowledge of, and extensive hands-on experience with, relevant molecular (e.g. PCR, DNA manipulation) and cell biology techniques (e.g. primary and derivative cell culture and transfection).
  • Preferred candidates will have experience in oncology, development of biomarker assays, and their implementation in clinical trials.
  • Candidates must have excellent communication skills and the ability to work with scientists and associates from multiple laboratories, disciplines and departments.
  • A proven track record, including authorship of and / or contributions to, publications in top tier journals is required.



This is a local hire only designated position, as relocation assistance is not available for the position

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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