South San Francisco
California, United States of America
The Ocular Group in Translational Immunology Department is seeking a motivated, interactive and flexible Senior Scientific Researcher to perform in vivo studies and in vitro characterization of preclinical endpoints. The successful candidate will be responsible for developing in vivo models of ocular diseases such as Glaucoma and AMD, and will use complementary approaches to assess retinal structure and function. This individual is expected to work effectively in a highly collaborative team setting to evaluate therapeutic candidates for blinding retinal diseases.
With a solid in vivo experience and murine handling, the successful candidate will be in charge of experimental design and execution. In addition to ocular model induction, the candidate will perform intravitreal and subretinal injections and use in vivo multimodal imaging techniques (OCT, fundus, angiography). Retinal function will be assessed by electroretinography (ERG, pERG, VEP) and behavioral testing. Specific responsibilities will include ocular tissue collection, microdissection and processing for immunohistochemistry, cellular and molecular biology approaches. This individual will be responsible for data analysis, report generation and communication.
The successful applicant will have a PhD in neuroscience, immunology, cell biology, or related field, preferably with a background in retina cell biology
2+ years experience in academic or industry laboratory setting
Experience with ocular injections, microdissection and electrophysiology will be required
Good oral/written communication skills, problem-solving, flexibility, and the ability to integrate detailed analysis into a larger disease-oriented context will be expected.
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
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