South San Francisco
California, United States of America
We are seeking a postdoctoral fellow to work on the molecular mechanisms of Notch receptor activation. This position would leverage a suite of unique reagents that selectively target Notch receptors and ligands, crystal structures, as well as relevant cell-based and animal models to elucidate differences in receptor-ligand interactions. The candidate will have the opportunity to apply this knowledge to investigate the molecular interplay between various receptor and ligands in the context of cell-type specification of the lung epithelium during homeostasis, injury, and repair.
The postdoc will be co-mentored between the Lafkas and Arron laboratories. Genentech has a proud tradition of world-class basic and translational research and the postdoctoral program here allows for important questions about fundamental biological mechanisms to be addressed independently of drug development programs. The large clinical trials conducted by the Roche group gives us unprecedented access to highly clinically characterized patients with matching data on treatment outcome, genetic variants, and disease state. A postdoc will be able to leverage these resources and study biological pathways of interest aided by world-class scientific infrastructure, and also gain exposure to the drug development process.
The successful candidate will be a recent or pending Ph.D. graduate with a background in Structural Biology, Biochemistry, and/or Cell Biology. They will also have demonstrated the ability to conduct high-quality research through publications in top tier, peer-reviewed scientific journals.
For information about Joe Arron's lab at Genentech, please go to: https://www.gene.com/scientists/our-scientists/joe-arron
For information about the Postdoctoral Program at Genentech, please go to: https://www.gene.com/careers/university-and-early-career/postdocs
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
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