South San Francisco, California
The Matsumoto lab, within the Structural Biology Department at Genentech, is seeking an innovative postdoctoral fellow to pursue engineering and structural characterization of immunoglobulins and their interactions with various cellular receptors and antigens. The postdoc will use protein engineering paired with X-ray crystallography and/or cryo-electron microscopy (cryo-EM) to explore various immunoglobulin formats for technology development and potential therapeutic applications. He/she will structurally characterize complexes of immunoglobulins with their receptors to elucidate the molecular mechanisms of recognition and understand structure-function relationships. The successful candidate will spearhead all aspects of his/her projects including antibody engineering, protein purification, biophysical characterization, and structure determination. Our department has state-of-the-art crystallography and cryo-EM facilities along with directed evolution platforms for protein engineering. This is a unique postdoc opportunity to pursue cutting-edge technology development and publication-oriented basic research in a highly collaborative, industrial setting.
Who You Are:
The successful candidate will be a highly motivated and detail-oriented researcher, driven to solve complex scientific problems, and able to work both independently and in a collaborative environment. Strong oral and written communication skills are required. Candidates must have a PhD. in structural biology, biochemistry, molecular biology, or a related field. Expertise in protein purification, biophysical characterization, and structure determination by X-ray crystallography and/or single-particle cryo-EM is required, as evidenced by a strong record of first-author publications in top peer-reviewed journals. Experience in protein engineering and directed evolution techniques, such as phage display, along with biophysical characterization methods for protein-protein interactions, such as surface-plasmon resonance (SPR) or bio-layer interferometry (BLI), are a plus.
More information on the Matsumoto Lab:
More information about the Genentech Postdoctoral Program:
Kumar N. et al. (2020) Structure of the Secretory Immunoglobulin A Core. Science 367(6481):1008-1014. DOI: 10.1126/science.aaz5807
Kumar N. et al. (2020) Structure of the Human Secretory Immunoglobulin M Core. bioRxiv DOI: 10.1101/2020.09.10.291138
Lombana T.N. et al. (2019) Production, Characterization, and in vivo Half-Life Extension of Polymeric IgA Molecules in Mice. MAbs 11(6):1122-1138. DOI: 10.1080/19420862.2019.1622940
Yau R.G. et al. (2017) Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Cell 171(4):918-933.e20. DOI: 10.1016/j.cell.2017.09.040
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