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Postdoctoral Fellow - Oncology, Shaw Lab

South San Francisco, California


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The Position

We have an opening for a talented Postdoctoral Fellow to join the laboratory of Dr. Andrey Shaw in the Oncology Department at Genentech. The focus of the lab is to use structural, biochemical and cellular approaches to study MAPK signaling in cancer with a specific focus on the RAF kinases and the KSR pseudokinases. The successful candidate will have experience in protein purification, protein characterization, enzymology and characterization of protein-protein interactions as well as experience in cellular experiments (tissue culture, IP western and mass spec, signaling experiments, siRNA/CRISPR) using mammalian tumor cells. The lab projects are focused on building mechanistic hypotheses using biochemical experiments/ approaches and testing those hypotheses in relevant cellular models. Experience with structural biology and biophysical methods including structural determination, mass spectrometry, fluorescence and microscopic based approaches to study protein-protein interactions in cells is also desirable. The lab has access to state of the art mass spectrometry facilities, a structural biology group, automation for high-throughput screening, access to libraries of small molecule compounds as well as access to in vivo mouse model development.

Requirements:

The qualified individual will possess a Ph.D. in Biochemistry, Cell Biology or related field with a solid publication record. Excellent communication and writing skills as well as a track record of working in highly collaborative environments is a must.

Relevant Lab Publications:

  • Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS.  Kinase regulation by hydrophobic spine assembly in cancer.  Mol Cell Biol 2015;35:264-276.
  • Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS.  Allosteric activation of functionally asymmetric RAF kinse dimers.  Cell 2013;154:1036-1046.
  • Hu J, Yu H, Kornev A, Zhao J, Filbert EL, Taylor SS, Shaw AS.  Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of the kinase suppressor of Ras, CRAF and BRAF.  Proc Natl Acad Sci 2011;108:6067-6072.
  • Lin J, Harding A, Giurisato E, Shaw AS. KSR1 modulates the sensitivity of the MAPK pathway activation in T cells without altering fundamental system outputs. Mol Cell Biol. 2009;29:2082-2091.

More information about the Shaw Lab:

https://www.gene.com/scientists/our-scientists/andrey-shaw

More information about the Genentech Postdoctoral Program:

https://www.gene.com/careers/university-and-early-career/postdocs

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Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

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