South San Francisco, California
An opportunity for a chemical biologist / protein biochemist is available to join a chemical biology group in the Department of Infectious Diseases. The group utilizes a multidisciplinary molecular approach for target validation across different therapeutic areas including immunology, infectious diseases, and pathogenic bacteria. Recent efforts focus on the synthesis and use of small molecule probes in combination with mass spectrometry metaproteomics to quantitate aberrant microbial protein families in gastrointestinal tract diseases.
The successful candidate will be responsible for chemical and peptide synthesis, enzymology, assay design, and proteomics to discover microbial proteins of therapeutic interest, as well as in the subsequent protein characterization by analytical methods (affinity purification, RP-HPLC, SDS-PAGE and Western analysis). This individual will also investigate the functional mechanism of bioactive ligands by biochemical, biophysical and cellular biochemistry methods. This is a basic research position that requires critical thinking, flexibility, multitasking and the ability to learn new techniques.
Ph.D. in chemical biology, biochemistry, or related discipline with 2 or more years of postdoctoral or industry experience in biochemistry, proteomics, enzymology or relevant areas
Track record of completing challenging technical problems independently and creatively, exemplified by publication of research in high-quality scientific journals.
Experience in protein expression and purification, biochemical and cellular assays, construct design and molecular biology is required.
Experience in bacterial culture, human tissue culture, and cell biology is advantageous
Molecular understanding of small molecule: protein interactions is desirable
Highly organized, motivated, work independently and collaboratively, team-oriented
Strong analytical, organizational, and communication skills
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
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