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Sr Scientific Researcher, Translational Genomics and the Center for Advanced Light Microscopy (CALM)

South San Francisco, California


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The Position

We are seeking a Senior Scientific Researcher to work in the Department of Translational Genomics and the Center for Advanced Light Microscopy (CALM) in the Department of Research Pathology to support and integrate imaging efforts to contribute to our Translational Genomics effort to help drive functional and cellular/tissue genomics across the Genentech Research Organization. Translational Genomics spans the interface of human genetics, functional genomics, molecular biology, cellular and tissue profiling, disease model engineering, and advanced computational methodology.  This is an exciting opportunity to apply imaging expertise to emerging therapeutic areas and support a diverse portfolio of imaging modalities.

In this role you will engage with researchers working in different disease areas and researchers in the Translational Genomics department to implement a wide variety of imaging tools and strategies to support optical pooled screening, imaging of 3D cultures such as organoids and ALI cultures.   You will enable efforts to translate imaging assays into high throughput screens to produce quantitative results.  You will apply your in-depth knowledge of microscopy platforms and image analysis skills to a dynamic and fast-paced research environment and be able to adapt your skills as needs change. You will work in a fast-paced and highly collaborative environment to address important questions from our research community.  

Who you are:

  • The candidate must have a BS/MS/PhD in Genetics, Cancer Biology, Immunology, Neuroscience, or a related discipline.

  • The candidate must have hands-on experience in a diverse array of imaging technologies from widefield epifluorescence, confocal and live cell imaging platforms.

  • Prior experience in high throughput screening and automation of imaging is preferred.  

  • The successful candidate must have experience designing and independently executing and interpreting image-based assays on multiple imaging platforms or in support of multiple scientific programs.  Working knowledge of image analysis programs like FIJI, CellProfiler, and/or MatLab is a plus.

  • Strong candidates will have the ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects.

  • Ideal candidates will have good oral and written communication skills.

  • Candidates must be responsive in team environments and be able to meet pre-defined deadlines.

About Us:

The Department of Pathology provides pathology expertise and tissue-based analysis to support basic scientific discoveries, development of drug targets, and biomarkers using both human tissues and animal models in support of drug development throughout the pipeline. Pathologists use their scientific and veterinary or medical backgrounds to integrate data from sources throughout the company into a coherent analysis of human disease and disease models. The pathologists’ collaborative support of Genentech scientists includes histopathology interpretive expertise informed by traditional diagnostic categories as well as by detailed and expert understanding of molecular and cellular biology. These activities are enabled by the pathology core (P-core) labs that include necropsy, clinical pathology, histopathology, immunohistochemistry / in situ hybridization, a human tissue biorepository, advanced light microscopy, electron microscopy and digital pathology, and translational tissue technologies.  The Department provides high quality pathology support to laboratory and clinical scientists engaged in biomarker strategy/development/deployment across the drug development pipeline. These activities can extend into “late stage” clinical development efforts (Phase III clinical trials).

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Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.


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