South San Francisco, California
The Biomarker Discovery OMNI department is seeking two motivated and interactive Senior Scientific Researchers to perform research related to biomarker discovery in remyelination, multiple sclerosis, and ALS. Successful candidates will implement a variety of in vitro and in vivo molecular, proteomic, and cellular techniques to elucidate disease pathways and mechanism, identify relevant biomarkers, and make intellectual as well as technical contributions to the team. These positions offer extensive collaboration with the Neuroscience department.
Assist the team in identifying predictive, prognostic, and pharmacodynamic biomarkers for molecularly targeted therapies in multiple sclerosis and ALS. Specific responsibilities will include: establishing and utilizing in vitro and preclinical models to promote biomarker discovery efforts and enable mechanistic understanding of pathways and underlying disease biology, performing exploratory disease-oriented research from human disease cohorts and clinical trial samples, contributing to experimental design/planning, collaborating with cross-functional groups, analyzing data, and presenting results.
PhD in a relevant field (Neuroscience, immunology, biochemistry, cell biology, molecular biology), postdoctoral experience preferred
Record of scientific achievement with publications in high-quality journals that demonstrate project leadership, expertise, and knowledge
Evidence of collaboration; enjoy working in a multi-disciplinary team environment but are also able to work independently to design, execute, and interpret experiments
Clear oral/written communication
Excellent time management and organizational skills, attention to detail
Ability to integrate detailed analyses into a larger disease-oriented context
Experience with commonly-used data analysis methods and software, R/Python is a plus
Examples of preferred skills:
Experience with human iPSC generation, maintenance and differentiation into CNS cell types and/or brain organoids
Cell culture experience with primary rodent tissue and mammalian cell lines
Proficiency conducting in vivo or ex vivo experiments with rodent models
Experience designing and conducting experiments to generate large, unbiased discovery datasets (ex: RNAseq, lipidomics, proteomics, etc)
Experience in the design, development, validation and execution of quantitative biochemical assays
Experience with microscopy and/or high content image analysis
Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
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