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Senior Scientific Researcher, Neuroprotection

South San Francisco, California

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The Position

The Biomarker Discovery OMNI department is seeking two motivated and interactive Senior Scientific Researchers to perform research related to biomarker discovery in remyelination, multiple sclerosis, and ALS. Successful candidates will implement a variety of in vitro and in vivo molecular, proteomic, and cellular techniques to elucidate disease pathways and mechanism, identify relevant biomarkers, and make intellectual as well as technical contributions to the team. These positions offer extensive collaboration with the Neuroscience department.


Assist the team in identifying predictive, prognostic, and pharmacodynamic biomarkers for molecularly targeted therapies in multiple sclerosis and ALS. Specific responsibilities will include: establishing and utilizing in vitro and preclinical models to promote biomarker discovery efforts and enable mechanistic understanding of pathways and underlying disease biology, performing exploratory disease-oriented research from human disease cohorts and clinical trial samples, contributing to experimental design/planning, collaborating with cross-functional groups, analyzing data, and presenting results.


  • PhD in a relevant field (Neuroscience, immunology, biochemistry, cell biology, molecular biology), postdoctoral experience preferred

  • Record of scientific achievement with publications in high-quality journals that demonstrate project leadership, expertise, and knowledge

  • Evidence of collaboration; enjoy working in a multi-disciplinary team environment but are also able to work independently to design, execute, and interpret experiments

  • Clear oral/written communication

  • Excellent time management and organizational skills, attention to detail

  • Ability to integrate detailed analyses into a larger disease-oriented context

  • Experience with commonly-used data analysis methods and software, R/Python is a plus

Examples of preferred skills:

  • Experience with human iPSC generation, maintenance and differentiation into CNS cell types and/or brain organoids

  • Cell culture experience with primary rodent tissue and mammalian cell lines

  • Proficiency conducting in vivo or ex vivo experiments with rodent models

  • Experience designing and conducting experiments to generate large, unbiased discovery datasets (ex: RNAseq, lipidomics, proteomics, etc)

  • Experience in the design, development, validation and execution of quantitative biochemical assays

  • Experience with microscopy and/or high content image analysis


Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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