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Mfg/Sr Technician - BioProcess

South San Francisco, California

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The Position

The BioProcess Manufacturing Technician/Senior Bioprocess Manufacturing Technician is responsible for producing innovative biotherapeutic medicine by interfacing with highly automated production systems and controls in cGMP manufacturing environment, and maintaining areas in high state of inspection preparedness. The incumbent in this role: 

  • Operates production equipment for cell culture or purification that may include culture growth, process monitoring, sampling, harvesting, purification, formulation, freeze thaw and transfer.

  • Performs media/buffer solution preparation operations. 

  • Maintains records and clean room environment to comply with regulatory requirements utilizing current Good Manufacturing Practices (cGMP) and Standard Operating Procedures (SOP).

We are hiring for both Day and Night shift.


  • Operate systems that clean and sterilize tanks and filtration systems. 

  • Prepare solutions for the production process.

  • Review documentation and check all calculations (e.g. tickets, labels, equipment reading).

  • Troubleshoot equipment and process problems.

  • Comply with safety requirements, cGMP, SOP and manufacturing documentation.

  • Use automation to perform production operations.

  • Operate automated systems for equipment operation.

  • Assemble and prepare equipment for production.

  • Partner with coworkers and supervisor to effectively troubleshoot minor equipment and process issues.

  • Foster a positive safety culture.

  • Recognize problems, investigate and suggest potential solutions.

  • Identify deviation from accepted practices

  • Operate bioreactors, centrifuges, other harvest systems and protein purification units.

  • Operate and clean fixed tank and filtration systems

  • Operate large scale column chromatography systems.

  • Operate small-scale cell culture areas and systems by operating cleaning, set up, and maintaining 20L bioreactors; inoculating and maintaining spinner seed cultures using aseptic techniques, maintaining cell banks; and performing general seed lab operations.

  • Perform solution preparation activities (media and buffer make-up).

  • Clean, assemble, and sterilize equipment using glass washers and autoclaves.

  • Perform automated CIP and SIP of fixed equipment.


The level of the position will depend on the qualifications of the selected candidate.

  • BA/BS in life/physical sciences or related discipline (preferred), AA degree and 1+ year related experience, or High School diploma with college-level course work in biological science, physical sciences or at least 2+ years of relevant experience

  • Strong knowledge of at least one manufacturing department with an understanding of process impact of other areas.

  • Understanding of the theory, concepts, and regulations behind biopharma technology and processes. 

  • Good problem solving, mechanical aptitude, interpersonal communication and team skills.

  • Self-starter with strong focus on quality, details and results.

  • Effective time management and organizational skills.

  • Possess proficiency in business applications including inventory control systems. 

  • Must be able to be flexible in work assignments, work weekends, off shifts and overtime as required.  



Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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