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Senior Scientific Researcher, Ophthalmology Biomarker Discovery

South San Francisco, California


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The Position

The Biomarker Discovery OMNI department is seeking a motivated, interactive and flexible Senior Scientific Researcher to participate in biomarker discovery and reverse translational work. This role will focus on deep molecular phenotyping of degenerative retinal diseases using leading-edge molecular technology. The successful candidate will use single cell genomics and spatial transcriptomics to identify pathways, targets and biomarkers, and will be expected to make intellectual as well as technical contributions to the team. This position is a rare opportunity to conduct basic research and immediately incorporate those findings into the clinical development of our therapeutic programs.

Responsibilities:

  • Assist the team in identifying biomarkers for molecularly targeted therapies in retinal disease.

  • Performing exploratory disease-oriented research utilizing samples and data from human disease cohorts

  • Processing and analyzing clinical trial samples, data analysis and presentation, and contributing to experimental design/planning.

Requirements:

  • Ph.D. in Neurobiology, Biochemistry, Molecular Biology, or a related discipline. Research experience in academic or industry setting, preferably 3 or more years. Recent graduates with an outstanding record of achievement are also strongly encouraged to apply.

  • Demonstrated ability to independently design and conduct experimental procedures and work collaboratively in a fast-paced team environment.

  • Practical experience with scRNA-Seq, ATAC-Seq, spatial transcriptomics and/or advanced microscopy is highly desired.

  • Familiarity with protein biochemistry, Next Generation Sequencing (NGS), basic bioinformatics/biostatistics, in vitro differentiation cultures (2D and 3D), or demonstrated research experience in retinal biology/neurodegenerative diseases will be an advantage.

  • Excellent organizational skills and oral/written communication skills, problem-solving, flexibility, and the ability to integrate detailed analysis into a larger disease-oriented context will be expected.

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Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.


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