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Scientist, Drug Metabolism and Pharmacokinetics

South San Francisco, California

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The Position

We are seeking an exceptional individual for a Scientist position within the in vitro ADME group in the Small Molecule Drug Metabolism and Pharmacokinetics Department. The successful candidate will have extensive experience in both LC-MS/MS method development and structural characterization of biological polymers such as peptides and nucleic acids with a track record of in vitro biological assay development and technical problem solving.  S/he will primarily support discovery and development of new modalities of drugs utilizing various in vitro ADME assays including but not limited to plasma and tissue protein binding, metabolic stability and reaction enzyme phenotyping.  Additionally, the successful candidate is expected to explore emerging in vitro ADME techniques and conduct investigational research to address project-specific translational DMPK issues such as IVIVC.  This role will involve new assay development and exploration of novel scientific ideas and methodologies using various in vitro biological systems in combination with advanced mass spectrometry.


  • Ph.D. in Biological Sciences/Pharmaceutics/Chemistry or other relevant field with 0-2 years of post-doctoral or industrial experience as proven by a solid publication record. 

  • Scientific curiosity and hands on experience with LC-MS/MS required.    

  • Passion for lab-based research with versatile laboratory skills. 

  • Comprehensive understanding of drug metabolism and ADME principles including enzyme kinetics and IVIVE is desired.  

  • Preference will be given to candidates with solid research experience in biological mass spectrometry including LC-MS/MS analysis and structural characterization of peptides and nucleic acids, metabolomics and proteomics.

  • The candidate must be highly motivated, detail oriented and organized with excellent communication skills (both oral and written) and a good team player able to mentor and positively influence team members.

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Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

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Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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