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Scientist/Sr Scientist, QSP/PKPD Modeling & Simulation Scientist (level flexible)

South San Francisco, California

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The Position


The Translational & Systems Pharmacology Group within the PKPD Department at Genentech, Inc. is seeking a QSP/PKPD Modeling & Simulation Scientist who is driven to enhance drug development through quantitative modeling and simulation of PKPD and biological systems. Our group supports projects in various stages of research and development across a range of therapeutic areas and molecule types/formats. We comprise scientists with PhDs in computational disciplines with expertise in mechanistic biological modeling and simulation, data-driven modeling, bioinformatics and systems biology, computational algorithm and tool development, and translating complex biology into quantitative models. We work closely with collaborators across all disciplines in therapeutic areas such as oncology and cancer immunotherapy, immune and inflammatory disorders, ocular disease, neurological disorders, and more. Efficient communication and collaboration with biological and clinical collaborators are critical skills. The group has a significant external presence, with a growing list of publications in highly regarded journals in the field, numerous oral presentations, academic seminars, and workshop leadership. Our members are leaders of various interest groups, conference programming committees, and working groups in the field of pharmaceutical modeling and simulation. In addition to our application of PKPD and systems modeling approaches in support of drug development, we are also committed to the development of new technical approaches, algorithms, and tools to advance the field.


  • Develop and apply mechanistic PKPD and systems pharmacology models in various

  • therapeutic areas including immune & inflammatory disease, oncology, and other disease areas, to support our drug development pipeline.

  • Independently strategize, plan, execute, and report QSP and PKPD modeling activities, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences.

  • Work in close partnership with other scientists in Modeling and Simulation, Clinical Pharmacology, Clinical Science, Informatics, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions.

  • Contribute to best practices on application of QSP and mechanistic PKPD in drug development

  • Present results at cross-functional teams, department meetings, review committees, and conferences.

  • Adapt and thrive in an interactive, team-oriented culture.


  • Ph.D in chemical, biomedical, or other relevant engineering fields, pharmaceutical sciences, or a related discipline.

  • Typical post-PhD experience requirements are: Associate Scientist, 0-3 years; Scientists, ~3-6 years; Senior Scientist, ~7-12 years; Principle Scientist, ~13+ years.

  • Proficiency with PKPD and systems modeling approaches such as differential equations, logic, stochastic, agent-based, and/or other advanced mechanistic modeling approaches is essential, as is experience with relevant software or programming languages (e.g., MATLAB/Simbiology, R, or C).

  • Excellent communication and interpersonal skills and the ability to work independently and effectively on cross-functional teams.

  • Strong leadership skills and the ability to influence project team collaborators.

  • Strong track record of external scientific presentation and publication, commensurate with hiring level

  • Managerial experience beneficial but not required for senior level positions (Sr Sci, Prin Sci)

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

The next step is yours. To apply today, click on the "Apply for this job" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.

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